| Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis. | |
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MedLine Citation:
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PMID: 15619415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-three patients with cardiac sarcoidosis were studied echocardiographically before and after (mean follow-up 88 months) steroid therapy to determine the effectiveness of corticosteroids to prevent left ventricular (LV) remodeling and improve LV contractility. In patients with initial LV ejection fractions (LVEFs) >or=55%, long-term steroid therapy showed preventive effects for LV remodeling and LV function. Patients with LVEF <54% showed significant reductions of LV volumes and LVEF improvement. However, in patients with LVEFs <30%, steroid therapy resulted in neither LV volume reductions nor improved LVEFs. In the early or middle stage of the disease, steroid therapy may be protective or therapeutic in preventing LV remodeling and preserving LV function. However, it may not be as effective in the late stage. |
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Authors:
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Chiung-Zuan Chiu; Satoshi Nakatani; Guican Zhang; Teruo Tachibana; Fumio Ohmori; Masakazu Yamagishi; Masafumi Kitakaze; Hitonobu Tomoike; Kunio Miyatake |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 95 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-27 Completed Date: 2005-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 143-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, National Cardiovascular Center, Suita, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiomyopathies / complications, drug therapy* Female Follow-Up Studies Glucocorticoids / pharmacology*, therapeutic use Humans Male Middle Aged Prednisolone / pharmacology*, therapeutic use Retrospective Studies Sarcoidosis / complications, drug therapy* Time Factors Ventricular Remodeling / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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