Document Detail

Prevention of left ventricular remodeling by percutaneous transluminal coronary angioplasty performed 24 hours after the onset of acute myocardial infarction.
MedLine Citation:
PMID:  10590189     Owner:  NLM     Status:  MEDLINE    
It remains controversial whether percutaneous transluminal coronary angioplasty (PTCA) performed 24 hours after the onset of acute myocardial infarction (AMI) in coronary arteries with 99% stenosis is useful in preserving left ventricular function. We investigated the effectiveness of PTCA in preventing left ventricular remodeling when it was performed 24 hours after the onset of AMI in infarct-related coronary arteries (IRCAs) having 99% stenosis and thrombolysis in myocardial infarction (TIMI) grade 3 flow. The subjects were 19 patients with AMI (anterior wall, 9 patients; inferior wall, 7 patients; and non-Q, 3 patients) who, within 24 hours of the onset of AMI, underwent coronary angiography and left ventriculography during the acute and/ or chronic phases. The patients were divided into a PTCA group, comprised of patients in whom PTCA was successfully performed 24 hours after the onset of AMI (n = 10), and a non-PTCA group (n = 9). The non-PCTA group included patients who were successfully reperfused by thrombolysis and did not include patients who had spontaneous reperfusion or reperfusion after PTCA. In the non-PTCA group, the left ventricular end-diastolic volume (mean +/- SD) was significantly increased in the chronic phase (86 +/- 23 mL/m(2)) as compared with the acute phase (67 +/- 13 mL/m(2)), whereas in the PTCA group no significant difference was observed between end-diastolic volumes in the acute and chronic phases (67 +/- 26 and 68 +/- 13 mL/m(2), respectively). Left ventricular remodeling is prevented by PTCA when it is performed 24 hours after the onset of AMI in IRCAs with 99% stenosis and TIMI grade 3 flow.
K Kanamasa; K Ishikawa; I Ogawa; T Nakabayashi
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  9     ISSN:  0929-5305     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-01     Completed Date:  2000-03-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
The First Department of Internal Medicine, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama, Osaka 589-8511, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Constriction, Pathologic / therapy
Evaluation Studies as Topic
Middle Aged
Myocardial Infarction / therapy*
Stroke Volume
Time Factors
Ventricular Remodeling*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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