Document Detail

Prevention of ischemia-reperfusion lung injury by inhaled nitric oxide in neonatal piglets.
MedLine Citation:
PMID:  8964737     Owner:  NLM     Status:  MEDLINE    
Lung ischemia-reperfusion results in a decrease in the release of nitric oxide (NO) by the pulmonary endothelium. NO may have lung-protective effects by decreasing neutrophil accumulation in the lung. We tested whether NO inhalation would attenuate reperfusion-induced endothelial dysfunction and increases in microvascular permeability and total pulmonary vascular resistance (RT) by preventing neutrophil lung accumulation. After baseline determinations of RT, coefficient of filtration (Kfc), and circulating neutrophil counts, isolated neonatal piglet lungs were subjected to a 1-h period of ischemia followed by a 1-h period of blood reperfusion and reventilation with or without addition of NO (10 ppm). NO prevented reperfusion-induced increases in RT and Kfc, as well as the decrease in circulating neutrophils. After reperfusion, increases in Kfc were correlated with decreases in circulating neutrophils. NO prevented reperfusion-induced decrease in endothelium-dependent relaxation in precontracted pulmonary arterial rings. This demonstrates that inhaled NO prevents microvascular injury, endothelial dysfunction, and pulmonary neutrophil accumulation in a neonatal piglet model of lung ischemia-reperfusion.
F Barbotin-Larrieu; M Mazmanian; B Baudet; H Détruit; A Chapelier; J M Libert; P Dartevelle; P Hervé
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  80     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  782-8     Citation Subset:  IM    
Laboratoire de Chirurgie Expérimentale, Hôpital Marie Lannelongue, Université Paris-Sud, France.
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MeSH Terms
Animals, Newborn
Calcimycin / pharmacology
Hemodynamics / drug effects
Ischemia / prevention & control*
Lung / drug effects*
Muscle, Smooth, Vascular / drug effects*
Nitric Oxide / pharmacology*
Time Factors
Reg. No./Substance:
10102-43-9/Nitric Oxide; 52665-69-7/Calcimycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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