Document Detail

Prevention of intractable partial seizures by intermittent vagal stimulation in humans: preliminary results.
MedLine Citation:
PMID:  2121469     Owner:  NLM     Status:  MEDLINE    
Intermittent stimulation of the vagus nerve in four patients resulted in complete seizure control in two, a 40% reduction of seizure frequency in one, and no change in seizure frequency in the other. Side effects (hoarseness, stimulation sensation in the neck, and hiccups) were transient and occurred concomitantly with stimulation. All patients tolerated increasing stimulation parameters well. The results, however, are inconclusive because of the brief duration (6-12 months) of follow-up. Vagal stimulation represents a novel approach for seizure control in patients who have intractable epilepsy, but additional studies are needed to clarify the efficacy and safety of the procedure and to define selection criteria for patients.
J K Penry; J C Dean
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  31 Suppl 2     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1990  
Date Detail:
Created Date:  1990-12-04     Completed Date:  1990-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S40-3     Citation Subset:  IM    
Department of Neurology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
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MeSH Terms
Electric Stimulation Therapy* / adverse effects,  methods
Epilepsies, Partial / therapy*
Prostheses and Implants
Vagus Nerve*

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