Document Detail

Prevention of induced atherosclerosis by diversion of bile or blockade of intestinal lymphatics in dogs.
MedLine Citation:
PMID:  817679     Owner:  NLM     Status:  MEDLINE    
The prevention of induced hypercholesterolemia and atherosclerosis was studied by means of intestinal lymphatic blockade and of bile diversion in the dog. Hypercholesterolemia and atherosclerosis were produced by high cholesterol feeding after induction of hypothyroidism with radio-iodine plus thiouracil. Complete diversion of bile, by shunting all bile into the urinary bladder, effectively prevented hypercholesterolemia and atherosclerosis; in contrast, blockade of the intestinal lymphatics failed to prevent the consequences of the atherogenic regimen, because of the development of collateral lymphatic channels.
P J Wilk; R C Karipineni; D Pertsemlidis; C A Danese
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  183     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-14     Citation Subset:  AIM; IM    
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MeSH Terms
Arteriosclerosis / etiology,  prevention & control*
Biliary Fistula / etiology
Biliary Tract Surgical Procedures*
Cholesterol / blood
Cholesterol, Dietary / administration & dosage
Collateral Circulation
Diet, Atherogenic
Disease Models, Animal
Hypercholesterolemia / prevention & control
Hypothyroidism / chemically induced
Intestinal Absorption
Intestine, Small / surgery
Iodine Radioisotopes
Lymphatic System / physiology,  surgery*
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Iodine Radioisotopes; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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