Document Detail


Prevention of increases in blood pressure and left ventricular mass and remodeling of resistance arteries in young New Zealand genetically hypertensive rats: the effects of chronic treatment with valsartan, enalapril and felodipine.
MedLine Citation:
PMID:  10754398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relative efficacy of three antihypertensive drugs in the prevention of further elevation of blood pressure (BP) and cardiovascular structural remodeling in 4-week-old genetically hypertensive (GH) rats was studied by means of two complementary methods, stereology and myography. Four to 10-week-old GH rats were treated with valsartan (10 mg/kg/day), enalapril (10 mg/kg/day) or felodipine (30 mg/kg/day). Untreated GH and normotensive control rats of Wistar origin served as controls. Tail-cuff systolic SBP was measured weekly and left ventricular (LV) mass determined at the end of the experiment. Mesenteric resistance arteries (MRA) were either fixed by perfusion, embedded in Technovit and sections stained for stereological analysis, or mounted on a wire myograph for structural and functional measurements. BP and LV mass were significantly reduced by all drugs; decreases in BP and LV mass were smaller after felodipine treatment. Valsartan and enalapril caused a decrease in BP to normotensive control values. Felodipine kept BP at the 4-week level and prevented further rise with age. Valsartan caused hypotrophic outward remodeling of MRA, enalapril eutrophic outward remodeling and felodipine hypotrophic remodeling. Myograph measurements showed remodeling of the same order. While all drugs lowered the media/lumen ratio in GH to normal, the outward remodeling after valsartan and enalapril indicates that valsartan and enalapril might be more effective in reversing the inward remodeling of resistance arteries found in essential hypertension.
Authors:
J M Ledingham; E L Phelan; M A Cross; R Laverty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of vascular research     Volume:  37     ISSN:  1018-1172     ISO Abbreviation:  J. Vasc. Res.     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-06-14     Completed Date:  2000-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  134-45     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Affiliation:
Department of Pharmacology, University of Otago, School of Medical Sciences, Dunedin, New Zealand. janet.ledingham@stonebow.otago.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / administration & dosage,  pharmacology*
Blood Pressure
Body Weight
Enalapril / administration & dosage,  pharmacology*
Felodipine / administration & dosage,  pharmacology*
Heart Ventricles / pathology*
Hypertension / pathology,  prevention & control*
Hypertrophy, Left Ventricular / prevention & control*
Mesenteric Arteries / pathology*
Rats
Rats, Inbred SHR
Rats, Wistar
Tetrazoles / administration & dosage,  pharmacology*
Valine / administration & dosage,  analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Tetrazoles; 137862-53-4/valsartan; 7004-03-7/Valine; 72509-76-3/Felodipine; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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