| Prevention of inappropriate ICD shocks in patients with Brugada syndrome. | |
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MedLine Citation:
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PMID: 19760052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In Brugada syndrome implantable cardioverter defibrillator (ICD) therapy is associated with a high rate of inappropriate therapies, mainly due to supraventricular tachyarrhythmias (SVT) (2.7-14.1%/year). Aim of the present study was to evaluate a single ventricular fibrillation (VF) detection zone with a high cut-off rate with respect to prevention of inappropriate ICD shock due to SVT and safety of this programming. METHODS: Sixty-one consecutive patients (mean age 42.6 +/- 12.9 years; 41 males) diagnosed with Brugada syndrome and implanted with an ICD were included. ICDs were prospectively programmed with a single VF detection zone and a cut-off rate of 222 beats/minute (bpm). A maximum of six shocks with the maximal shock energy were programmed. The minimal follow-up was 1 year. RESULTS: During a follow-up of 47.6 +/- 23.1 months seven patients (2.91%/year) received appropriate ICD shocks. No patient suffered from syncope or died. Five patients (2.07%/year) received inappropriate ICD shocks: four patients due to T-wave oversensing and only one patient (0.4%/year) due to SVT (atrial fibrillation with a ventricular rate of >222 bpm). CONCLUSIONS: Programming of a single, high-rate VF zone in patients with Brugada syndrome and an implanted defibrillator is safe. Such programming may be associated with reduced inappropriate defibrillator discharges. A single detection zone with a high VF cut-off rate can be recommended in patients with Brugada syndrome. |
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Authors:
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Christian Veltmann; Juergen Kuschyk; Rainer Schimpf; Florian Streitner; Nina Schoene; Martin Borggrefe; Christian Wolpert |
Publication Detail:
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Type: Journal Article Date: 2009-09-16 |
Journal Detail:
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Title: Clinical research in cardiology : official journal of the German Cardiac Society Volume: 99 ISSN: 1861-0692 ISO Abbreviation: Clin Res Cardiol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-22 Completed Date: 2010-04-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264123 Medline TA: Clin Res Cardiol Country: Germany |
Other Details:
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Languages: eng Pagination: 37-44 Citation Subset: IM |
Affiliation:
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1st Department of Medicine-Cardiology, University Medical Centre Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. christian.veltmann@umm.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brugada Syndrome / therapy* Death, Sudden, Cardiac / prevention & control* Defibrillators, Implantable* / adverse effects Equipment Failure Female Follow-Up Studies Humans Male Middle Aged Prospective Studies Tachycardia, Supraventricular / complications, etiology Ventricular Fibrillation / etiology, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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