Document Detail

Prevention of hyperoxia-mediated pulmonary inflammation in neonatal rats by caffeine.
MedLine Citation:
PMID:  22878872     Owner:  NLM     Status:  Publisher    
In preterm human infants, briefly elevated concentrations of high oxygen are associated with a prolonged increase in blood chemokine concentrations and development of bronchopulmonary dysplasia (BPD). Caffeine given to preterm infants for prevention or treatment of apnoea has been shown to reduce the rate of BPD.Here, we tested the hypotheses that infant rats exposed to a combination of caffeine and hyperoxia would be less susceptible to lung injury than those exposed to hyperoxia alone and that caffeine decreases the pulmonary tissue expression of chemokines and leukocyte influx following hyperoxia.Using 6 day-old rat pups, we demonstrate that 24 h of 80% oxygen exposure caused pulmonary recruitment of neutrophils and macrophages. High levels of oxygen upregulated the expression of the CXC chemokines, cytokine-induced neutrophil chemoattractant-1 and macrophage inflammatory protein-2, the CC chemokine monocyte chemoattractant protein 1, as well as the proinflammatory cytokines tumour necrosis factor-α and interleukin-6, as measured by realtime PCR Administration of caffeine (10 mg·kg(-1) body weight) attenuated chemokine and cytokine upregulation, as well as the influx of CD11b+, ED-1+ and MPO+ leukocytes.These experiments suggest that protective effects of caffeine in the neonatal lung are mediated at least in part by reduction of pulmonary inflammation.
Ulrike Weichelt; Ruhuye Cay; Thomas Schmitz; Evelyn Strauss; Marco Sifringer; Christoph Bührer; Stefanie Endesfelder
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Charité University Medical Center, Berlin, Germany.
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