Document Detail


Prevention of giant coronary artery aneurysms in Kawasaki disease by intravenous gamma globulin therapy.
MedLine Citation:
PMID:  2456378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have demonstrated the efficacy of intravenous gamma globulin in the prevention of coronary artery abnormalities in Kawasaki disease. We retrospectively reviewed our single-hospital experience with patients in whom Kawasaki disease was diagnosed from January 1979 to July 1987. Only 3 of 68 (4%) patients treated with intravenous gamma globulin in the first 10 days of illness developed coronary artery abnormalities (one of the three had abnormalities before gamma globulin therapy), in comparison with 39 of 119 (33%) patients not treated with gamma globulin (p less than 0.001). Giant coronary artery aneurysms, which are associated with the greatest morbidity and mortality rates in Kawasaki disease, developed in none of the 68 patients treated with gamma globulin but in 7 of 119 patients (6%) not treated with gamma globulin (p = 0.04). Intravenous gamma globulin appears to be effective not only in reducing the overall prevalence of coronary artery abnormalities in Kawasaki disease but, more important, in preventing the formation of giant aneurysms, the most serious form of coronary abnormality after this illness.
Authors:
A H Rowley; C E Duffy; S T Shulman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  113     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-08     Completed Date:  1988-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  290-4     Citation Subset:  AIM; IM    
Affiliation:
Division of Infectious Diseases, Children's Memorial Hospital, Chicago, IL 60614.
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Coronary Aneurysm / prevention & control*
Echocardiography
Female
Follow-Up Studies
Humans
Immunization, Passive*
Infant
Injections, Intravenous
Male
Mucocutaneous Lymph Node Syndrome / complications*
Retrospective Studies
gamma-Globulins / administration & dosage*
Grant Support
ID/Acronym/Agency:
HL34545/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/gamma-Globulins
Comments/Corrections
Comment In:
J Pediatr. 1989 Jun;114(6):1065-6   [PMID:  2470887 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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