Document Detail

Prevention of femoral vein occlusion by local injection of Thrombolysin in the rat.
MedLine Citation:
PMID:  422823     Owner:  NLM     Status:  MEDLINE    
An experimental model was developed that will produce femoral vein occlusion greater than 90% of the time in rats weighing less than 500 grams. This standard venous clot, produced by combining intimal trauma with local venous stasis, can simulate clinical crush and replantation problems. Using this standard clot model, Thrombolysin was injected in the femoral artery after trauma to the vein but before venous stasis. Femoral vein patency was determined at the end of the 30 minute period of venous stasis. With the appropriate dosage, ipsilateral venous occlusion was prevented (P less than 0.00001) without preventing contralateral venous occlusion (P less than 0.02). Except for decreased fibrinogen levels, there was no significant change in the factors studied between the control and experimental groups. It is possible, therefore, to prevent thrombosis in a vein with intimal damage, even in the presence of a low-flow state by the local injection of Thrombolysin, without producing systemic anticoagulation.
A L Dellon; R M Curtis; C Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of hand surgery     Volume:  4     ISSN:  0363-5023     ISO Abbreviation:  J Hand Surg Am     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-05-16     Completed Date:  1979-05-16     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  7609631     Medline TA:  J Hand Surg Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-8     Citation Subset:  IM    
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MeSH Terms
Blood Coagulation / drug effects
Disease Models, Animal
Femoral Vein*
Fibrinolytic Agents / pharmacology,  therapeutic use*
Plasminogen / pharmacology
Streptokinase / pharmacology
Thrombosis / prevention & control*
Reg. No./Substance:
0/Fibrinolytic Agents; 9001-91-6/Plasminogen; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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