| Prevention of femoral vein occlusion by local injection of Thrombolysin in the rat. | |
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MedLine Citation:
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PMID: 422823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An experimental model was developed that will produce femoral vein occlusion greater than 90% of the time in rats weighing less than 500 grams. This standard venous clot, produced by combining intimal trauma with local venous stasis, can simulate clinical crush and replantation problems. Using this standard clot model, Thrombolysin was injected in the femoral artery after trauma to the vein but before venous stasis. Femoral vein patency was determined at the end of the 30 minute period of venous stasis. With the appropriate dosage, ipsilateral venous occlusion was prevented (P less than 0.00001) without preventing contralateral venous occlusion (P less than 0.02). Except for decreased fibrinogen levels, there was no significant change in the factors studied between the control and experimental groups. It is possible, therefore, to prevent thrombosis in a vein with intimal damage, even in the presence of a low-flow state by the local injection of Thrombolysin, without producing systemic anticoagulation. |
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Authors:
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A L Dellon; R M Curtis; C Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of hand surgery Volume: 4 ISSN: 0363-5023 ISO Abbreviation: J Hand Surg Am Publication Date: 1979 Mar |
Date Detail:
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Created Date: 1979-05-16 Completed Date: 1979-05-16 Revised Date: 2009-06-08 |
Medline Journal Info:
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Nlm Unique ID: 7609631 Medline TA: J Hand Surg Am Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 121-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation / drug effects Disease Models, Animal Femoral Vein* Fibrinolytic Agents / pharmacology, therapeutic use* Plasminogen / pharmacology Rats Streptokinase / pharmacology Thrombosis / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 9001-91-6/Plasminogen; EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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