Document Detail


Prevention of diabetic retinal capillary pericyte degeneration and loss by pancreatic islet allograft.
MedLine Citation:
PMID:  2954769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Degeneration and loss of retinal capillary pericytes are characteristic features of diabetic retinopathy. The effect of pancreatic islet cell allotransplantation across a major histocompatibility barrier on diabetic pericyte changes was examined in streptozotocin induced diabetic rats 14 months post-transplantation. Morphological studies of the retinal microvasculature were carried out using qualitative and quantitative morphological techniques. We describe significant prevention of pericyte degeneration and loss after successful allotransplantation suggesting that pancreatic islet allograft is a promising therapeutical approach in the prevention of diabetic retinopathy.
Authors:
S Chakrabarti; A A Sima; W J Tze; J Tai
Related Documents :
15104169 - Influence of cataract on the multifocal erg recording--a pre- and postoperative compari...
21143769 - Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced exper...
10482109 - Topless optic disk syndrome without maternal diabetes mellitus.
22937169 - Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satel...
14683529 - Vascular endothelial growth factor (vegf) fails to improve blood flow and to promote co...
23572519 - Metabolism of glycerol, glucose, and lactate in the citric acid cycle prior to incorpor...
1727729 - Psychomotor slowing is associated with distal symmetrical polyneuropathy in adults with...
9439539 - Glucose metabolism in severe malaria: minimal model analysis of the intravenous glucose...
24887549 - Hypoglycemic and hepatoprotective effects of polysaccharides from artemisia sphaeroceph...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current eye research     Volume:  6     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-07     Completed Date:  1987-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  649-58     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Capillaries / pathology
Diabetes Mellitus, Experimental
Diabetic Retinopathy / prevention & control*
Endothelium / pathology
Islets of Langerhans Transplantation*
Male
Rats
Rats, Inbred Lew
Retinal Degeneration / prevention & control*
Retinal Vessels* / pathology
Streptozocin
Chemical
Reg. No./Substance:
18883-66-4/Streptozocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cutaneous allergy to mustard in a salad maker.
Next Document:  Adjustment of the seated workplace--with special reference to heights and inclinations of seat and t...