Document Detail

Prevention of diabetic retinal capillary pericyte degeneration and loss by pancreatic islet allograft.
MedLine Citation:
PMID:  2954769     Owner:  NLM     Status:  MEDLINE    
Degeneration and loss of retinal capillary pericytes are characteristic features of diabetic retinopathy. The effect of pancreatic islet cell allotransplantation across a major histocompatibility barrier on diabetic pericyte changes was examined in streptozotocin induced diabetic rats 14 months post-transplantation. Morphological studies of the retinal microvasculature were carried out using qualitative and quantitative morphological techniques. We describe significant prevention of pericyte degeneration and loss after successful allotransplantation suggesting that pancreatic islet allograft is a promising therapeutical approach in the prevention of diabetic retinopathy.
S Chakrabarti; A A Sima; W J Tze; J Tai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current eye research     Volume:  6     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-07     Completed Date:  1987-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  649-58     Citation Subset:  IM    
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MeSH Terms
Capillaries / pathology
Diabetes Mellitus, Experimental
Diabetic Retinopathy / prevention & control*
Endothelium / pathology
Islets of Langerhans Transplantation*
Rats, Inbred Lew
Retinal Degeneration / prevention & control*
Retinal Vessels* / pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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