Document Detail

Prevention of deep vein thrombosis in orthopaedic surgery. Comparison of two different treatment protocols with low molecular weight heparin ('Fluxum').
MedLine Citation:
PMID:  1316259     Owner:  NLM     Status:  MEDLINE    
The efficacy of two treatment protocols with a low molecular weight heparin used for the prevention of post-operative deep vein thrombosis was compared in 40 patients undergoing hip replacement surgery. The aim was to assess whether the different timing--2 hours before (Group A, 19 patients) or 2 hours after (Group B, 21 patients) the surgical operation--of the first dose administered (15,000 aXaU) of a therapeutic cycle of 7 days could affect the results, both with respect to the preventive efficacy and to the risk of haemorrhage often connected with antithrombotic therapy. The results showed that the incidence of deep vein thrombosis was very similar and extremely low in the two groups, only 1 patient in each group having a positive diagnosis on phlebography. The effectiveness of a single daily dose of 15,000 aXaU in orthopaedic surgery was also confirmed. This dose guaranteed effective prophylaxis against the onset of deep vein thrombosis and did not appear to have any local side-effects (such as burning or pain at the site of injection) which could diminish patient compliance.
A M Laguardia; G C Caroli
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Current medical research and opinion     Volume:  12     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-18     Completed Date:  1992-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  584-93     Citation Subset:  IM    
1st Service of Anaesthesia and Reanimation, Istituto di Ricovero e Cura a Carattere Scientificio, Bologna, Italy.
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MeSH Terms
Clinical Protocols
Drug Administration Schedule
Heparin, Low-Molecular-Weight / administration & dosage*
Hip Prosthesis
Middle Aged
Postoperative Complications / prevention & control*
Pulmonary Embolism / etiology,  radionuclide imaging
Risk Factors
Thrombophlebitis / etiology,  prevention & control*
Reg. No./Substance:
0/Heparin, Low-Molecular-Weight

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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