|Prevention of coronary atherosclerosis by the use of combination therapy with antioxidant coenzyme Q10 and statins.|
|PMID: 15821319 Owner: NLM Status: MEDLINE|
|The goal of the present research was to assess the efficacy of combination treatment with antioxidant coenzyme Q10 and simvastatin as well as coenzyme Q10 without statin therapy in order to prevent coronary atherosclerosis. 42 outpatients were divided into 2 groups: receiving coenzyme Q10 (Hasco-Lek, Poland) 60mg daily and its combination with simvastatin (zocor, vasilip) 10mg daily for an 8-week period. The treatment with coenzyme Q10 demonstrated its potential independent role in positive modification of oxidative stress, antiatherogenic fraction of lipid profile, atherogenic ratio, platelet aggregability. Taking into consideration the obtained results the study supports the use of coenzyme Q10 in combination with statins. Suggested attractive approach may result in complete correction of dislipidemia, reverse of endothelial dysfunction, reduce degree of oxidative stress and platelet aggregability. Consequently such a combination may be beneficial in preventing of further development of atherosclerosis in native coronary arteries as well as in bypass grafts in all coronary heart disease patients with or without myocardial revascularization.|
|G Chapidze; S Kapanadze; N Dolidze; Z Bachutashvili; N Latsabidze|
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|Type: Comparative Study; Evaluation Studies; Journal Article|
|Title: Georgian medical news Volume: - ISSN: 1512-0112 ISO Abbreviation: Georgian Med News Publication Date: 2005 Jan|
|Created Date: 2005-04-11 Completed Date: 2005-04-29 Revised Date: 2008-05-21|
Medline Journal Info:
|Nlm Unique ID: 101218222 Medline TA: Georgian Med News Country: Georgia (Republic)|
|Languages: eng Pagination: 20-5 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
administration & dosage,
Antioxidants / administration & dosage, therapeutic use*
Coronary Artery Bypass
Coronary Artery Disease / blood, prevention & control*
Coronary Disease / blood, drug therapy, surgery
Data Interpretation, Statistical
Drug Therapy, Combination
Lipids / blood
Nitric Oxide / blood
Simvastatin / administration & dosage, therapeutic use*
Triglycerides / blood
Ubiquinone / administration & dosage, analogs & derivatives*, therapeutic use*
|0/Antilipemic Agents; 0/Antioxidants; 0/Coenzymes; 0/Lipids; 0/Triglycerides; 10102-43-9/Nitric Oxide; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10; 79902-63-9/Simvastatin|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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