Document Detail


Prevention of cold-induced increase in blood pressure of rats by captopril.
MedLine Citation:
PMID:  2045137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the possibility that the renin-angiotensin system may play a role in the development of cold-induced hypertension, three groups of rats were used. Two groups were exposed to cold (5 +/- 2 degrees C) while the remaining group was kept at 26 +/- 2 degrees C. One group of cold-treated rats received food into which captopril (0.06% by weight) had been thoroughly mixed. The remaining two groups received the same food but without captopril. Systolic blood pressure of the untreated, cold-exposed group increased significantly above that of the warm-adapted, control group within 4 weeks of exposure to cold. In contrast, chronic treatment with captopril prevented the elevation of blood pressure. Rats were killed after 4 months of exposure to cold. At death, the heart, kidneys, adrenal glands, and interscapular brown fat pad were removed and weighed. Although captopril prevented the elevation of blood pressure in cold-treated rats, it did not prevent hypertrophy of the kidneys, heart, and interstitial brown adipose tissue that characteristically accompanies exposure to cold. Thus, chronic treatment with captopril prevented the elevation of blood pressure when administered at the time exposure to cold was initiated. It also reduced the elevated blood pressure of cold-treated rats when administered after blood pressure became elevated. This suggests that the renin-angiotensin system may play a role in the elevation of blood pressure during exposure to cold.
Authors:
O Shechtman; M J Fregly; P van Bergen; P E Papanek
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  17     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-12     Completed Date:  1991-07-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  763-70     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Florida, College of Medicine, Gainesville 32610.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Captopril / pharmacology*
Cold Temperature*
Hypertension / drug therapy,  prevention & control*
Male
Organ Specificity
Rats
Rats, Inbred Strains
Renin-Angiotensin System / drug effects
Grant Support
ID/Acronym/Agency:
HL-39154-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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