Document Detail


Prevention of chromate induced oxidative stress by alpha-lipoic acid.
MedLine Citation:
PMID:  15997482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity.
Authors:
Roli Budhwar; Sushil Kumar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  43     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-04     Completed Date:  2005-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  531-5     Citation Subset:  IM    
Affiliation:
Environmental Carcinogenesis Section, Industrial Toxicology Research Center, Post Box 80, MG Marg, Lucknow 226001, UP, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Carbon / chemistry
Catalase / metabolism
Chromates / pharmacology*
Chromium / chemistry,  poisoning
Glutathione / metabolism
Glutathione Reductase / metabolism
Lipid Peroxidation
Liver / metabolism
Male
Mice
Oxidants / metabolism
Oxidative Stress*
Oxygen / metabolism
Potassium Dichromate / chemistry
Superoxide Dismutase / metabolism
Thioctic Acid / chemistry,  metabolism,  pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Chromates; 0/Oxidants; 62-46-4/Thioctic Acid; 70-18-8/Glutathione; 7440-44-0/Carbon; 7440-47-3/Chromium; 7778-50-9/Potassium Dichromate; 7782-44-7/Oxygen; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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