Document Detail

Prevention of chemotherapy-induced leukemia and of leukemia relapses.
MedLine Citation:
PMID:  1725055     Owner:  NLM     Status:  MEDLINE    
Fifty percent of patients with the myelodysplastic syndrome, frequently following treatment by radiation or chemotherapy, have prognostically unfavorable deletions of the long arms of chromosomes 5 and 7, or trisomy 8, as have the 25% of patients with acute myeloblastic leukemia where remissions last 6-12 months, and where relapse cannot be prevented. In contrast, patients with prognostically favorable cytogenetics (translocation 15; 17 or 8; 21 or inversion 16) maintenance chemotherapy may prevent relapses. Of chronic myelocytic leukemia patients, 85% can achieve hematological remission with interferon alpha, and 40% a partial cytogenetic remission, which probably delays relapse.
E J Freireich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical oncology and tumor pharmacotherapy     Volume:  8     ISSN:  0736-0118     ISO Abbreviation:  Med Oncol Tumor Pharmacother     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-30     Completed Date:  1992-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8405039     Medline TA:  Med Oncol Tumor Pharmacother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
Adult Leukemia Research Program, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Interferons / therapeutic use
Leukemia / chemically induced,  prevention & control*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
Remission Induction / methods
Reg. No./Substance:
0/Antineoplastic Agents; 9008-11-1/Interferons

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