Document Detail


Prevention of cerebral vasospasm by calcitonin gene-related peptide slow-release tablet after subarachnoid hemorrhage in monkeys.
MedLine Citation:
PMID:  8905755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The goal of this work was to investigate the efficacy of a calcitonin gene-related peptide (CGRP) slow-release tablet (CGRP tablet) for the prevention of cerebral vasospasm after subarachnoid hemorrhage (SAH). METHODS: Experimental SAH was produced in 10 cynomolgus monkeys by placing a clot around the internal carotid artery bifurcation (Day 0). In five animals, CGRP tablets (1200 micrograms of CGRP) were then placed in the cerebrospinal fluid space (CGRP group). In two animals, placebo tablets were similarly placed (placebo group). The remaining three animals were treated with no tablets after SAH (SAH group). A series of angiographic analyses were performed, before SAH and on Days 7 and 14, to examine changes in the diameters of the ipsilateral internal carotid artery, middle cerebral artery, and anterior cerebral artery. The CGRP concentration in the cerebrospinal fluid taken before each angiogram was also determined. RESULTS: In the SAH and placebo groups, cerebral vasospasm developed on Day 7 (54.8% of the pre-SAH value at the internal carotid artery, 62.3% at the middle cerebral artery, 51.3% at the anterior cerebral artery, and 56.1% as an average of the three arteries). In the CGRP group, vasospasm was significantly ameliorated at the middle cerebral artery, at the anterior cerebral artery, and on average (81.7, 81.1, and 75.7%, P < 0.05, 0.03, and 0.02, respectively). The CGRP concentration was positive only on Day 7 for the CGRP group (6.5 nmol/L). CONCLUSION: The CGRP tablet prevented cerebral vasospasm after SAH and may have significant potential for the treatment of patients with SAH.
Authors:
T Inoue; H Shimizu; T Kaminuma; M Tajima; K Watabe; T Yoshimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  39     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-28     Completed Date:  1997-02-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  984-90     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcitonin Gene-Related Peptide / administration & dosage*,  therapeutic use
Cerebral Angiography
Delayed-Action Preparations
Ischemic Attack, Transient / prevention & control*,  radiography
Macaca fascicularis
Male
Rabbits
Subarachnoid Hemorrhage / complications*,  drug therapy*
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 83652-28-2/Calcitonin Gene-Related Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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