Document Detail

Prevention of cardioembolic stroke in patients with atrial fibrillation.
MedLine Citation:
PMID:  20936927     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation (AF) is the most common cardiac arrhythmia and an important independent stroke risk factor, especially in the elderly. This article provides the reader with an overview as well as an update on primary and secondary stroke prevention strategies in patients with AF. Vitamin K antagonists remain the cornerstone therapy in AF patients at high risk of stroke. Both aspirin monotherapy and the combination of aspirin and clopidogrel are inferior to vitamin K antagonists in patients with AF. The new direct thrombin inhibitor dabigatran is at least as effective as warfarin and leads to a significant and clinically relevant decrease in hemorrhagic stroke and intracranial bleeds. Interventional therapies such as percutaneous closure of the left atrial appendage or radiofrequency catheter ablation have not yet been proven to decrease the stroke risk in patients with AF.
Ralph Weber; Hans-Christoph Diener; Christian Weimar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  8     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1405-15     Citation Subset:  IM    
Department of Neurology and Stroke Center, University Duisburg-Essen, Hufelandstrasse 55, Essen, Germany.
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MeSH Terms
Anticoagulants / therapeutic use*
Atrial Fibrillation / complications,  drug therapy*,  surgery
Intracranial Hemorrhages / etiology,  prevention & control
Platelet Aggregation Inhibitors / therapeutic use
Primary Prevention / methods
Risk Factors
Secondary Prevention / methods
Stroke / etiology,  prevention & control*
Vitamin K / antagonists & inhibitors
Reg. No./Substance:
0/Anticoagulants; 0/Platelet Aggregation Inhibitors; 12001-79-5/Vitamin K

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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