Document Detail

Prevention of cancer: restriction of nutritional energy intake (joules).
MedLine Citation:
PMID:  2904336     Owner:  NLM     Status:  MEDLINE    
1. The reduction of nutritional energy intake (joules) often reduces the incidence of both spontaneous and induced cancers in humans and experimental animals in an approximately dose-dependent manner. 2. To achieve the best preventive effect, the reduction of dietary intake should begin well before the carcinogen insult, should be intense enough (lowering the intake of joules by at least approx. 25-30%) and should last a long time, preferably even life-long. 3. This preventive effect depends upon the strain, sex and age of animals, the kind of carcinogenic insult and also the susceptibility of the target tissue. 4. The mechanism by which the dietary restriction may exert its protective action may involve changes in the hormonal equilibria, influences upon the immuno-surveillance, changes of activities of enzymes involved in carcinogen metabolism and other factors. 5. Since over-eating and the resulting obesity constitutes a pronounced risk factor for the incidence of cancer and other diseases, lowering the nutritional energy intake represents today the simplest, cheapest and most effective way to prevent cancer in the general population.
G Hocman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Comparative biochemistry and physiology. A, Comparative physiology     Volume:  91     ISSN:  0300-9629     ISO Abbreviation:  Comp Biochem Physiol A Comp Physiol     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-26     Completed Date:  1989-01-26     Revised Date:  2008-10-30    
Medline Journal Info:
Nlm Unique ID:  1276312     Medline TA:  Comp Biochem Physiol A Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-20     Citation Subset:  IM    
Research Institute of Preventive Medicine, Bratislava, Czechoslovakia.
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MeSH Terms
Body Weight
Energy Intake*
Neoplasms / prevention & control*
Neoplasms, Experimental / prevention & control

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