Document Detail


PREVENTION BY ANTAGONISTS OF THE TOXIC ACTION OF 5-HYDROXYTRYPTAMINE ON PREGNANCY.
MedLine Citation:
PMID:  14066139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As 5-hydroxytryptamine can interrupt pregnancy in all its stages in mice and as pregnancy can be protected from the action of 5-hydroxytryptamine by either progesterone or by prolactin only in early (days 1 to 6) but not in late pregnancy (day 14), the present experiments with two antagonists of 5-hydroxytryptamine, namely methysergide and cyproheptadine, were carried out. Each compound antagonized the action of 5-hydroxytryptamine in late pregnancy. The toxic effects produced by 5-hydroxytryptamine are probably due to a direct action on the placental circulation which is prevented by the antagonists. In early pregnancy, methysergide prevented the effect of 5-hydroxytryptamine, which is believed then to act on the central nervous system, interfering with luteal activity. Cyproheptadine alone interrupted early pregnancy, an action which was prevented by progesterone.
Authors:
E POULSON; J M ROBSON
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology and chemotherapy     Volume:  21     ISSN:  0366-0826     ISO Abbreviation:  Br J Pharmacol Chemother     Publication Date:  1963 Aug 
Date Detail:
Created Date:  1964-02-01     Completed Date:  1996-12-01     Revised Date:  2011-09-28    
Medline Journal Info:
Nlm Unique ID:  0154627     Medline TA:  Br J Pharmacol Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  150-4     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Mice*
Pregnancy, Animal*
Research*
Serotonin*
Serotonin Uptake Inhibitors*
Toxicology*
Chemical
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 50-67-9/Serotonin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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