| Prevention of bronchoconstriction in sensitized guinea pigs: efficacy of common prophylactic drugs. | |
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MedLine Citation:
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PMID: 15239967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Efficacy of beta2-agonists (B2), anticholinergics, corticosteroids, anti-inflammatory drugs or antihistamines against methacholine, histamine, or allergen-induced lung constriction was tested in ovalbumin sensitized guinea pigs. Airway resistance (Raw) and parenchymal damping (G) and elastance (H) were determined from low-frequency forced oscillatory input impedance (ZL). ZL was measured under control conditions, during iv infusions of methacholine, and following iv boluses of histamine or ovalbumin. In decreasing potency, ipratropium, salmeterol, fluticasone or cromoglycate reduced the methacholine-induced increases in Raw and G. Only antihistamines had any effects on the histamine-induced increased in Raw, G, and H. The ovalbumin-induced increases in Raw, G and H in the control animals (120 +/- 90%, 201 +/- 126%, 86 +/- 71%) were markedly reduced by pretreatments with antihistamines (18 +/- 11%, 13 +/- 9%, 3+/- 3%) and cromoglycate (29 +/- 13%, 35 +/- 22%, 18 +/- 10%). Bronchoconstriction induced by muscarinic receptor stimulation is inhibited by anticholinergic, anti-inflammatory or beta2-agonist pretreatment; antihistaminic or anti-inflammatory premedication is beneficial if the release of histamine via an exposure to allergen is responsible for the fall in lung function. |
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Authors:
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Nathalie Schütz; Ferenc Peták; Constance Barazzone-Argiroffo; Peter D Sly; Walid Habre |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 141 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-07-08 Completed Date: 2004-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 167-78 Citation Subset: IM |
Affiliation:
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Division of Anesthesiological Investigations, University of Geneva, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Agonists
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pharmacology Albuterol / analogs & derivatives*, pharmacology Allergens / pharmacology Analysis of Variance Androstadienes / pharmacology Animals Anti-Inflammatory Agents Bronchial Hyperreactivity / chemically induced, prevention & control* Bronchoconstriction / drug effects* Bronchoconstrictor Agents / pharmacology* Bronchodilator Agents / pharmacology* Cholinergic Antagonists / pharmacology Cromolyn Sodium / pharmacology Dose-Response Relationship, Drug Drug Interactions Guinea Pigs Histamine / pharmacology Histamine H1 Antagonists / pharmacology* Ipratropium / pharmacology Male Methacholine Chloride / pharmacology Ovalbumin Receptors, Adrenergic, beta-2 / agonists |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Agonists; 0/Allergens; 0/Androstadienes; 0/Anti-Inflammatory Agents; 0/Bronchoconstrictor Agents; 0/Bronchodilator Agents; 0/Cholinergic Antagonists; 0/Histamine H1 Antagonists; 0/Receptors, Adrenergic, beta-2; 15826-37-6/Cromolyn Sodium; 18559-94-9/Albuterol; 51-45-6/Histamine; 60205-81-4/Ipratropium; 62-51-1/Methacholine Chloride; 89365-50-4/salmeterol; 9006-59-1/Ovalbumin; 90566-53-3/fluticasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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