| Prevention of biliary stent occlusion by ursodeoxycholic acid plus norfloxacin: a multicenter randomized trial. | |
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MedLine Citation:
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PMID: 10695627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a prospective randomized multicenter trial that tested the efficacy of combining ursodeoxycholic acid and norfloxacin in the prevention of polyethylene stent clogging in patients with obstructive jaundice due to an unresectable malignancy at the level of the common bile duct. After insertion of a 10-Fr straight polyethylene stent, patients were allocated to receive oral treatment with ursodeoxycholic acid and norfloxacin, or conservative treatment. The primary outcome measure was stent blockage within six months. Thirty-three patients (group I) received ursodeoxycholic acid and norfloxacin, and 29 received conservative treatment (group II). At six months, cumulative stent patency rate did not differ significantly between group I (47+/-11%, mean +/- SE, median 149 days) and group II patients (24+/-10%, mean +/- SE, median 100 days, P = 0.23, log-rank test). Four stents were clogged by ursodeoxycholic acid. Survival did not differ between the two groups. Combined therapy with ursodeoxycholic acid and norfloxacin failed to improve stent patency. Moreover, ursodeoxycholic acid can cause stent obstruction. |
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Authors:
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V De Lédinghen; B Person; J L Legoux; A Le Sidaner; B Desaint; M Greef; C Moesch; G Grollier; P Ingrand; D Sautereau; M Beauchant |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 45 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-17 Completed Date: 2000-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 145-50 Citation Subset: AIM; IM |
Affiliation:
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Centre Hospitalier Universitaire, Poitiers, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Infective Agents / therapeutic use* Cholagogues and Choleretics / therapeutic use* Cholestasis / therapy* Female Humans Male Norfloxacin / therapeutic use* Prospective Studies Stents* Time Factors Treatment Outcome Ursodeoxycholic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid; 70458-96-7/Norfloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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