Document Detail


Prevention of biliary stent occlusion by ursodeoxycholic acid plus norfloxacin: a multicenter randomized trial.
MedLine Citation:
PMID:  10695627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a prospective randomized multicenter trial that tested the efficacy of combining ursodeoxycholic acid and norfloxacin in the prevention of polyethylene stent clogging in patients with obstructive jaundice due to an unresectable malignancy at the level of the common bile duct. After insertion of a 10-Fr straight polyethylene stent, patients were allocated to receive oral treatment with ursodeoxycholic acid and norfloxacin, or conservative treatment. The primary outcome measure was stent blockage within six months. Thirty-three patients (group I) received ursodeoxycholic acid and norfloxacin, and 29 received conservative treatment (group II). At six months, cumulative stent patency rate did not differ significantly between group I (47+/-11%, mean +/- SE, median 149 days) and group II patients (24+/-10%, mean +/- SE, median 100 days, P = 0.23, log-rank test). Four stents were clogged by ursodeoxycholic acid. Survival did not differ between the two groups. Combined therapy with ursodeoxycholic acid and norfloxacin failed to improve stent patency. Moreover, ursodeoxycholic acid can cause stent obstruction.
Authors:
V De Lédinghen; B Person; J L Legoux; A Le Sidaner; B Desaint; M Greef; C Moesch; G Grollier; P Ingrand; D Sautereau; M Beauchant
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  45     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-17     Completed Date:  2000-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  AIM; IM    
Affiliation:
Centre Hospitalier Universitaire, Poitiers, France.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Infective Agents / therapeutic use*
Cholagogues and Choleretics / therapeutic use*
Cholestasis / therapy*
Female
Humans
Male
Norfloxacin / therapeutic use*
Prospective Studies
Stents*
Time Factors
Treatment Outcome
Ursodeoxycholic Acid / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid; 70458-96-7/Norfloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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