Document Detail

Prevention of arterial graft spasm by botulinum toxin: an in-vitro experiment.
MedLine Citation:
PMID:  19564207     Owner:  NLM     Status:  MEDLINE    
In coronary artery bypass surgery, arterial grafts result in improved patency rates. However, these grafts frequently fail due to spasm. Papaverine has been used to prevent graft spasm, but its effect is short-lived. Botulinum toxin inhibits muscle contraction for about three months. We investigated the usefulness of botulinum toxin in preventing arterial grafts spasm in vitro. Samples of abdominal aorta from male Wistar rats were cut into 2 mm rings and treated with various doses of botulinum toxin or papaverine for 30 min. All rings were stimulated with KCl and noradrenaline. Tension was recorded using myography. We compared constriction caused by noradrenaline or KCl in rings treated with botulinum toxin, or papaverine, or physiological salt solution (PSS) (control). In the presence of KCl and noradrenaline, almost all concentrations of botulinum toxin completely inhibited arterial contraction when compared with controls. Spasm prevention was lost after 60 min in rings with papaverine but persisted for 120 min in rings with botulinum toxin. In the histological examination, arterial wall structure was not destroyed by botulinum toxin. Botulinum toxin prevented arterial graft spasm in vitro and had a longer lasting effect than papaverine, with no toxic effect on the artery.
Eiji Murakami; Hisashi Iwata; Matsuhisa Imaizumi; Hirohumi Takemura
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2009-06-29
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  9     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-18     Completed Date:  2009-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
Department of General and Cardiothoracic Surgery, Gifu University, Gifu City, Gifu 501-1194, Japan.
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MeSH Terms
Aorta, Abdominal / drug effects*,  physiopathology,  transplantation
Aortic Diseases / physiopathology,  prevention & control*
Botulinum Toxins / pharmacology*
Cardiovascular Agents / pharmacology*
Dose-Response Relationship, Drug
Norepinephrine / pharmacology
Papaverine / pharmacology
Potassium Chloride / pharmacology
Rats, Wistar
Spasm / physiopathology,  prevention & control*
Time Factors
Vasoconstriction / drug effects*
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Botulinum Toxins; 0/Cardiovascular Agents; 0/Vasoconstrictor Agents; 0/botulinum toxin type C; 51-41-2/Norepinephrine; 58-74-2/Papaverine; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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