Document Detail


Prevention of aortocoronary vein-graft attrition with low-dose aspirin and triflusal, both associated with dipyridamole: a randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  2647494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A randomized, double-blind, placebo-controlled trial was performed in 209 patients to evaluate the efficacy of a low dose of aspirin plus dipyridamole or that of a new antiplatelet agent (triflusal) plus dipyridamole in the prevention of aortocoronary vein-graft occlusion. An angiographic control performed in 161 patients 9 days after surgery showed no significant differences between groups, but a new control on 138 of those patients 6 months later did show significant linear trends towards fewer distal anastomosis occlusions (P = 0.027) from the placebo (24%, 22/91) to the aspirin (16%, 17/106) and to the trifusal groups (12%, 10/86), and towards fewer new occlusions (P = 0.056) from 12% (9/78) to 10% (10/99) and to 2.6% (2/78), respectively, in the same groups. A multivariate logistic regression model, used to determine the effect of 33 variables on distal anastomosis occlusion at 6 months control, demonstrated that diameter of distal bed (P = 0.006), moderately to severely atherosclerotic distal bed (P = 0.003) and the interactions between poor distal bed and triflusal (P = 0.005) were independent predictors of occlusion. Thus, triflusal plus dipyridamole appeared superior to low-dose aspirin plus dipyridamole in the prevention of vein-graft occlusion, independently of coronary and vein-graft determinants of occlusion.
Authors:
P Guiteras; J Altimiras; A Arís; J M Augé; T Bassons; J Bonal; J M Caralps; C Castellarnau; C Crexells; M Masotti
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  10     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  159-67     Citation Subset:  IM    
Affiliation:
Cardiac Catheterization and Invasive Cardiology Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aspirin / administration & dosage*,  adverse effects
Clinical Trials as Topic
Coronary Artery Bypass*
Dipyridamole / administration & dosage*
Double-Blind Method
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Patient Compliance
Prospective Studies
Random Allocation
Salicylates / administration & dosage*,  adverse effects
Vascular Patency / drug effects*
Chemical
Reg. No./Substance:
0/Salicylates; 322-79-2/triflusal; 50-78-2/Aspirin; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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