| Prevention of amlodipine absorption by activated charcoal: effect of delay in charcoal administration. | |
| | |
MedLine Citation:
|
PMID: 9056049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: The purpose of this study was to investigate the effect of activated charcoal on the absorption of amlodipine, with special reference to delayed charcoal administration. METHODS: Thirty-two healthy volunteers, eight subjects in four parallel groups, ingested 10 mg of amlodipine on an empty stomach. Activated charcoal (25 g in 300 ml of water) was ingested either immediately afterwards or 2 h or 6 h after amlodipine, or amlodipine was ingested with 300 ml of water only (control). Plasma concentrations and the cumulative excretion of amlodipine into urine were measured by GC-MS for 96 h and 72 h, respectively. In addition, adsorption of amlodipine to charcoal was studied in vitro. RESULTS: Activated charcoal administered immediately after amlodipine reduced the amlodipine AUC(0.96 h) and the 72-h urinary excretion by 99% (P < 0.0005). After a delay of 2 h in charcoal administration the AUC(0.96 h) was reduced by 49% (P = 0.001), but after a delay of 6 h the reduction was 15% only (P = NS). At a charcoal:drug ratio of 5:1, about 90% of amlodipine was adsorbed by charcoal in vitro; at ratios of 10:1 and 20:1, adsorption was practically complete. CONCLUSIONS: Activated charcoal almost completely prevented amlodipine absorption when administered immediately after amlodipine ingestion. Charcoal also markedly reduced amlodipine absorption when given 2 h after amlodipine; in amlodipine overdose, administration of charcoal may be beneficial even later. We conclude that administration of activated charcoal is the method of choice to prevent absorption of amlodipine in amlodipine overdose. |
| | |
Authors:
|
K Laine; K T Kivistö; I Laakso; P J Neuvonen |
Related Documents
:
|
10658549 - Preventing commercial fishing deaths in alaska. 21340729 - Risk factors for severe retinopathy of prematurity in preterm low birth weight neonates. 21514859 - Neurological examination of late-preterm infants at term age. 22214879 - Electrophysiological measurements and analysis of nociception in human infants. 6997179 - Glucocorticoids in prevention of respiratory distress syndrome. 2998859 - Lithium suppresses hibernation in the turkish hamster. 2299439 - Married mothers' perceptions of their premature or term infants and the quality of thei... 15342829 - Perinatal stroke in children with motor impairment: a population-based study. 14648519 - Case report of a pressure ulcer in an infant receiving extracorporeal life support: the... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: British journal of clinical pharmacology Volume: 43 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1997 Jan |
Date Detail:
|
Created Date: 1997-05-29 Completed Date: 1997-05-29 Revised Date: 2009-10-02 |
Medline Journal Info:
|
Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adsorption
/
drug effects Adult Amlodipine / adverse effects, pharmacokinetics* Analysis of Variance Calcium Channel Blockers / adverse effects, pharmacokinetics* Charcoal / administration & dosage* Female Humans Intestinal Absorption* Male Overdose / prevention & control |
| Chemical | |
Reg. No./Substance:
|
0/Calcium Channel Blockers; 16291-96-6/Charcoal; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of the pharmacokinetics of lamotrigine in patients with chronic renal failure and healthy...
Next Document: Meloxicam pharmacokinetics in renal impairment.