Document Detail

Prevention of allergic sensitization by environmental control.
MedLine Citation:
PMID:  19671379     Owner:  NLM     Status:  MEDLINE    
For about 20 years, investigators have been attempting to design studies to reduce exposure to allergens in order to prevent the development of allergic sensitization and thus prevent the onset of allergic disease, particularly asthma. Seven such studies-environmental control studies-have attempted to accomplish this by changing the domestic environment into which a high-risk child is born. Some of these studies also included a dietary intervention aimed at reducing the risk of development of sensitization to food allergens. In this review, we summarize the seven studies, compare study designs, and evaluate the effectiveness of the environmental control measures adopted. We present published results, focusing on the most recent. There is great heterogeneity of results that cannot be explained by the variety of study designs alone. We propose that the next generation of primary prevention studies will be informed by epidemiologic studies of gene-environment interactions and will investigate the effects of tailor-made measures targeting individuals with specific susceptibilities who may benefit from specified interventions.
Angela Simpson; Adnan Custovic
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current allergy and asthma reports     Volume:  9     ISSN:  1534-6315     ISO Abbreviation:  Curr Allergy Asthma Rep     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-12     Completed Date:  2009-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101096440     Medline TA:  Curr Allergy Asthma Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  363-9     Citation Subset:  IM    
University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Second Floor, Education and Research Centre, Manchester, United Kingdom.
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MeSH Terms
Air Pollutants / immunology*
Allergens / immunology*
Asthma / prevention & control*
Clinical Trials as Topic
Environmental Exposure / prevention & control*
Environmental Monitoring
Reg. No./Substance:
0/Air Pollutants; 0/Allergens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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