| Prevention of activation of blood coagulation during acute coronary ischemic syndromes: beyond aspirin and heparin. | |
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MedLine Citation:
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PMID: 10341841 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many of the acute coronary ischemic syndromes are triggered by spontaneous or mechanical disruption of atherosclerotic plaques with resultant activation of platelets and coagulation. Given the central role of platelets and thrombin in arterial thrombosis, current strategies for its prevention and treatment focus on both inhibition of platelet aggregation and control of thrombin generation and activity. Although aspirin and unfractionated heparin are the cornerstones of current treatment strategies, both have limitations. This review will describe these limitations and discuss new antithrombotic agents developed for use in acute coronary ischemic syndromes and as adjuncts for percutaneous coronary revascularization procedures. |
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Authors:
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S M Bates; J I Weitz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cardiovascular research Volume: 41 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-06-07 Completed Date: 1999-06-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 418-32 Citation Subset: IM |
Affiliation:
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McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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therapeutic use* Aspirin / therapeutic use Fibrinolytic Agents / therapeutic use Heparin / therapeutic use Humans Myocardial Ischemia / drug therapy* Platelet Aggregation Inhibitors / therapeutic use Thrombin / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 9005-49-6/Heparin; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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