| Prevention of accelerated cell aging in the Werner syndrome. | |
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MedLine Citation:
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PMID: 16803993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the Werner syndrome (WS) fibroblasts have an increased life span and growth rate when treated with the p38 inhibitor SB203580. Additionally, the cellular morphology reverts to that seen in young normal fibroblasts. The p38 pathway is activated in young WS cells, associated with high levels of p21(WAF1) leading to cell cycle arrest, and is suppressed by SB203580. As these changes are also seen in telomerized WS cells, these data show that the growth problems seen in WS cells, and perhaps the accelerated in vivo aging, are due to a telomere-independent premature senescence mechanism. The suppression of this mechanism by SB203580 treatment suggests a route whereby WS may be amenable to therapeutic intervention. |
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Authors:
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Terence Davis; Michèle F Haughton; Christopher J Jones; David Kipling |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1067 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-06-28 Completed Date: 2006-07-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 243-7 Citation Subset: IM |
Affiliation:
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Department of Pathology, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, Wales, UK. davist2@cardiff.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Aging, Premature / prevention & control* Cell Aging / drug effects, genetics, physiology* Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21 / metabolism Enzyme Inhibitors / pharmacology Fibroblasts / drug effects, metabolism, pathology Humans Imidazoles / pharmacology Pyridines / pharmacology Telomerase / genetics, metabolism Telomere / genetics, metabolism Tumor Suppressor Protein p53 / metabolism Werner Syndrome / genetics*, pathology p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Enzyme Inhibitors; 0/Imidazoles; 0/Pyridines; 0/SB 203580; 0/Tumor Suppressor Protein p53; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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