Document Detail

Prevention of Type 2 diabetes mellitus. A review of the evidence and its application in a UK setting.
MedLine Citation:
PMID:  15089783     Owner:  NLM     Status:  MEDLINE    
Abstract Type 2 Diabetes mellitus (T2DM) is a complex metabolic, multifactorial disease, which affects the quality, quantity and style of life. People with T2DM have a life expectancy that can be shortened by as much as 15 years, with up to 75% dying of macrovascular complications. To reduce the impact of T2DM in the 21st century, we need an approach that not only optimally treats the person with established diabetes but also prevents diabetes from occurring in the first place. The best evidence for prevention of diabetes is for interventions that target individuals at highest risk. Targeting patients who have impaired glucose tolerance with lifestyle changes including physical activity and dietary factors has been shown to be effective in the Chinese, North American and Finnish populations. In order for such lifestyle interventions to be successful in other populations, they need to be culturally sensitive, individualized and sustained. Some pharmacological agents including metformin and acarbose have also been shown to be effective, although the profile of those who respond is different. There continues to be a need to develop and evaluate interventions that target communities and populations at risk in a UK setting.
M J Davies; J R Tringham; J Troughton; K K Khunti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  21     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-07-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  403-14     Citation Subset:  IM    
Department of Diabetes, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK.
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MeSH Terms
Diabetes Mellitus, Type 2 / prevention & control*
Glucose Intolerance / therapy
Great Britain
Hypoglycemic Agents / therapeutic use
Life Style
Mass Screening / methods
Risk Factors
Reg. No./Substance:
0/Hypoglycemic Agents
Comment In:
Diabet Med. 2005 Sep;22(9):1285-6; author reply 1286-7   [PMID:  16108865 ]

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