Document Detail


Prevention of malaria during pregnancy: assessing the effect of the distribution of IPTp through the national policy in Benin.
MedLine Citation:
PMID:  21292898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficiency of malaria prevention during pregnancy was compared between three studies in Benin for malaria infection of the placenta (MIP) and low birth weight (LBW). The first was carried out when chloroquine prophylaxis was still recommended, the second was an intermittent preventive treatment in pregnancy (IPTp) clinical trial comparing sulfadoxine pyrimetamine (SP) versus mefloquine, and the third was an observational study after SP-IPTp national implementation. We showed an association between the use of IPTp and the reduction of LBW (10% with national IPTp and 8.7% in IPTp trial versus 15.7% in pre-trial study). The effect on MIP was better in the trial (2.9% versus 11.2% and 16.7% for national IPTp and pre-trial studies, respectively). In spite of a good overall compliance with the national IPTp (with 84% of women taking at least one dose of SP), there are still failures in adherence to the directly observed therapy (DOT) scheme and needs for better training of health staff.
Authors:
Agnès Le Port; Gilles Cottrell; Célia Dechavanne; Valérie Briand; Aziz Bouraima; José Guerra; Isabelle Choudat; Achille Massougbodji; Benjamin Fayomi; Florence Migot-Nabias; André Garcia; Michel Cot
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  84     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-03-18     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-5     Citation Subset:  AIM; IM    
Affiliation:
Institut de Recherche pour le Développement (IRD), UMR216, Mère et Enfant Face aux Infections Tropicales, Paris, France. agnesleport@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Antimalarials / administration & dosage,  therapeutic use*
Benin / epidemiology
Chloroquine / administration & dosage,  therapeutic use*
Drug Combinations
Female
HIV Infections / parasitology
Health Policy*
Humans
Infant, Low Birth Weight
Infant, Newborn
Malaria / drug therapy,  prevention & control*
Maternal Age
Mefloquine / administration & dosage,  therapeutic use*
Multivariate Analysis
Placenta / parasitology
Pregnancy
Pregnancy Complications, Parasitic / prevention & control*
Pyrimethamine / administration & dosage,  therapeutic use*
Risk Factors
Sulfadoxine / administration & dosage,  therapeutic use*
Young Adult
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Drug Combinations; 2447-57-6/Sulfadoxine; 37338-39-9/fanasil, pyrimethamine drug combination; 53230-10-7/Mefloquine; 54-05-7/Chloroquine; 58-14-0/Pyrimethamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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