Document Detail


Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions.
MedLine Citation:
PMID:  16266772     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alzheimer's disease (AD) and cardiovascular disease (CVD) are syndromes of aging that share analogous lesions and risk factors, involving lipoproteins, oxidative damage and inflammation. Unlike in CVD, in AD, sensitive biomarkers are unknown, and high-risk groups are understudied. To identify potential prevention strategies in AD, we have focused on pre-clinical models (transgenic and amyloid infusion models), testing dietary/lifestyle factors strongly implicated in reducing risk in epidemiological studies. Initially, we reported the impact of non-steroidal anti-inflammatory drugs (NSAIDs), notably ibuprofen, which reduced amyloid accumulation, but suppressed few inflammatory markers and without reducing oxidative damage. Safety concerns with chronic NSAIDs led to a screen of alternative NSAIDs and identification of the phenolic anti-inflammatory/anti-oxidant compound curcumin, the yellow pigment in turmeric that we found targeted multiple AD pathogenic cascades. The dietary omega-3 fatty acid, docosahexaenoic acid (DHA), also limited amyloid, oxidative damage and synaptic and cognitive deficits in a transgenic mouse model. Both DHA and curcumin have favorable safety profiles, epidemiology and efficacy, and may exert general anti-aging benefits (anti-cancer and cardioprotective.).
Authors:
Greg M Cole; Giselle P Lim; Fusheng Yang; Bruce Teter; Aynun Begum; Qiulan Ma; Marni E Harris-White; Sally A Frautschy
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2005-11-02
Journal Detail:
Title:  Neurobiology of aging     Volume:  26 Suppl 1     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-06     Completed Date:  2006-03-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Affiliation:
Greater Los Angeles Veterans Affairs Healthcare System, Geriatric Research, Education and Clinical Center, Sepulveda, CA 91343, USA. gmcole@ucla.edu
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / prevention & control*
Animals
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Antioxidants / therapeutic use*
Curcumin / therapeutic use
Fatty Acids, Omega-3 / therapeutic use*
Flavonoids / therapeutic use*
Humans
Phenols / therapeutic use*
Grant Support
ID/Acronym/Agency:
AG021975/AG/NIA NIH HHS; AG10685/AG/NIA NIH HHS; AG13471/AG/NIA NIH HHS; NS43946/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antioxidants; 0/Fatty Acids, Omega-3; 0/Flavonoids; 0/Phenols; 0/polyphenols; 458-37-7/Curcumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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