Document Detail

Prevention of Adverse Pregnancy Outcomes With Low-Dose ASA in Early Pregnancy: New Perspectives for Future Randomized Trials.
MedLine Citation:
PMID:  21639969     Owner:  NLM     Status:  In-Data-Review    
Recent evidence suggests that treatment with low-dose acetylsalicylic acid (ASA) started early in pregnancy could prevent preeclampsia and intrauterine growth restriction (IUGR), two complications involving placental dysfunction. Preterm birth could also potentially be prevented, suggesting that it could share mechanisms of disease with preeclampsia and intrauterine growth restriction. Because there is new evidence that placental dysfunction can be predicted as early as in the first trimester, we argue that there is a need for randomized controlled trials of low-dose ASA for the prevention of preeclampsia, IUGR, and possibly preterm birth among nulliparous women with early indicators of placental dysfunction.
Emmanuel Bujold; Sylvie Tapp; Francois Audibert; Ema Ferreira; Jean-Claude Forest; Evelyne Rey; William D Fraser; Nils Chaillet; Yves Giguère
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC     Volume:  33     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-06-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  480-3     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Quebec QC, Centre de Recherche du Centre Hospitalier Universitaire de Québec (CRCHUQ), Quebec QC.
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