Document Detail

Preventing noise induced otoacoustic emission loss by increasing magnesium (Mg2+) intake in guinea-pigs.
MedLine Citation:
PMID:  14558727     Owner:  NLM     Status:  MEDLINE    
This study aimed to explore the effects of increased Mg2+ intake on the activity of the outer hair cells as manifested in Click and Distortion Evoked Otoacoustic Emissions (CEOAEs; DPOAEs) in 25 animals. Thirteen animals were fed with high Mg2+ intake (39 mmol Mg2+/l in drinking water) and 12 without the Mg2+ additive. The OAE amplitudes and frequency ranges as well as the DPOAE thresholds were affected significantly less by noise exposure in the animals fed Mg2+-enriched water. Following the exposure, the auditory recovery was faster in the high than the low Mg2+ animals (controls). In addition, a relationship was found between the Mg2+ level and the emission loss. The post-exposure measures may result from the effect of Mg2+ on cochlear metabolic processes and vascular microcirculation. The results demonstrate that pre-existing low Mg2+ levels will exacerbate noise induced hearing loss (NIHL), and increased Mg2+ intake provides a significant biological cochlear protective effect.
Joseph Attias; Ian Bresloff; Heidemarie Haupt; Fred Scheibe; Hartmut Ising
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of basic and clinical physiology and pharmacology     Volume:  14     ISSN:  0792-6855     ISO Abbreviation:  J Basic Clin Physiol Pharmacol     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-15     Completed Date:  2004-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9101750     Medline TA:  J Basic Clin Physiol Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  119-36     Citation Subset:  IM    
Department of Communication Disorders, Haifa University, Petach Tikva, Israel.
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MeSH Terms
Acoustic Stimulation
Erythrocytes / metabolism
Guinea Pigs
Hearing Loss / physiopathology,  prevention & control*
Magnesium / blood,  cerebrospinal fluid,  therapeutic use*
Otoacoustic Emissions, Spontaneous / drug effects*
Perilymph / metabolism
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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