| Preventing noise induced otoacoustic emission loss by increasing magnesium (Mg2+) intake in guinea-pigs. | |
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MedLine Citation:
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PMID: 14558727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to explore the effects of increased Mg2+ intake on the activity of the outer hair cells as manifested in Click and Distortion Evoked Otoacoustic Emissions (CEOAEs; DPOAEs) in 25 animals. Thirteen animals were fed with high Mg2+ intake (39 mmol Mg2+/l in drinking water) and 12 without the Mg2+ additive. The OAE amplitudes and frequency ranges as well as the DPOAE thresholds were affected significantly less by noise exposure in the animals fed Mg2+-enriched water. Following the exposure, the auditory recovery was faster in the high than the low Mg2+ animals (controls). In addition, a relationship was found between the Mg2+ level and the emission loss. The post-exposure measures may result from the effect of Mg2+ on cochlear metabolic processes and vascular microcirculation. The results demonstrate that pre-existing low Mg2+ levels will exacerbate noise induced hearing loss (NIHL), and increased Mg2+ intake provides a significant biological cochlear protective effect. |
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Authors:
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Joseph Attias; Ian Bresloff; Heidemarie Haupt; Fred Scheibe; Hartmut Ising |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of basic and clinical physiology and pharmacology Volume: 14 ISSN: 0792-6855 ISO Abbreviation: J Basic Clin Physiol Pharmacol Publication Date: 2003 |
Date Detail:
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Created Date: 2003-10-15 Completed Date: 2004-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9101750 Medline TA: J Basic Clin Physiol Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 119-36 Citation Subset: IM |
Affiliation:
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Department of Communication Disorders, Haifa University, Petach Tikva, Israel. attiasj@netvision.net.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Erythrocytes / metabolism Female Guinea Pigs Hearing Loss / physiopathology, prevention & control* Magnesium / blood, cerebrospinal fluid, therapeutic use* Male Otoacoustic Emissions, Spontaneous / drug effects* Perilymph / metabolism |
| Chemical | |
Reg. No./Substance:
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7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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