| Preventing and managing bronchiolitis obliterans syndrome after allogeneic hematopoietic cell transplantation. | |
| | |
MedLine Citation:
|
PMID: 21348593 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Bronchiolitis obliterans syndrome is a potentially fatal complication of allogeneic hematopoietic cell transplantation that is defined as the development of new fixed airflow obstruction within the first 2 years after transplantation. The prevalence of this syndrome is estimated to be 5.5% among all allogeneic hematopoietic cell transplantation recipients, and 14% among all long-term survivors who develop chronic graft-versus-host disease. Although little is known about the pathogenesis of this syndrome, there are now clear guidelines for clinical diagnosis of bronchiolitis obliterans syndrome, and there appear to be promising new approaches towards treatment that can significantly reduce the morbidity associated with corticosteroid therapy. Future research efforts should target the identification of clinical biomarkers for risk stratification, early diagnosis and treatment-response assessment. |
| | |
Authors:
|
Jason W Chien |
Related Documents
:
|
19309503 - Sheldon-hall syndrome. 16035043 - Epigenetic deregulation of genomic imprinting in human disorders and following assisted... 20691943 - Facial capillary malformation and dyke-davidoff-masson syndrome. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Expert review of respiratory medicine Volume: 5 ISSN: 1747-6356 ISO Abbreviation: Expert Rev Respir Med Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101278196 Medline TA: Expert Rev Respir Med Country: England |
Other Details:
|
Languages: eng Pagination: 127-35 Citation Subset: IM |
Affiliation:
|
Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N. D5-280, Seattle, WA 98109-1024, USA. jchien@fhcrc.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pathogenesis of indirect (secondary) acute lung injury.
Next Document: Long-Term Topical Antiglaucoma Medications Cause Enhanced Tenon's Capsule Fibroblast Proliferation a...