|Preventing long-term risk of obesity for two generations: prenatal physical activity is part of the puzzle.|
|Jump to Full Text|
|PMID: 23316363 Owner: NLM Status: MEDLINE|
|BACKGROUND: The period surrounding pregnancy has been identified as a risk period for overweight/obesity in both mother and child because of excessive gestational weight gain (GWG). The promotion of a healthy GWG is therefore of paramount importance in the context of the prevention of obesity in the current and next generations.
OBJECTIVE: To provide a comprehensive overview of the effect of prenatal physical activity interventions, alone or in combination with nutritional counselling, on GWG and to address whether preventing excessive GWG decreases the incidence of infant high birth weight and/or postpartum weight retention.
METHOD: A search of the PubMed database was conducted to identify all relevant studies. Nineteen studies were included in this review: 13 interventions combining physical activity, nutrition, and GWG counselling and 6 interventions including physical activity alone.
RESULTS: Prenatal lifestyle interventions promoting healthy eating and physical activity habits appear to be the most effective approach to prevent excessive GWG. Achievement of appropriate GWG may also decrease the incidence of high infant birth weight and postpartum weight retention.
CONCLUSION: Healthy eating habits during pregnancy, combined with an active lifestyle, may be important elements in the prevention of long-term risk of obesity for two generations.
|Stephanie-May Ruchat; Michelle F Mottola|
Related Documents :
|3816273 - Transcutaneous respiratory electromyographic monitoring.
23864443 - First-day weight loss predicts eventual weight nadir for breastfeeding newborns.
17081803 - Heparin-mediated extracorporeal low density lipoprotein precipitation as a possible the...
|Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2012-12-17|
|Title: Journal of pregnancy Volume: 2012 ISSN: 2090-2735 ISO Abbreviation: J Pregnancy Publication Date: 2012|
|Created Date: 2013-01-14 Completed Date: 2013-06-03 Revised Date: 2013-07-11|
Medline Journal Info:
|Nlm Unique ID: 101553823 Medline TA: J Pregnancy Country: Egypt|
|Languages: eng Pagination: 470247 Citation Subset: IM|
|R. Samuel McLaughlin Foundation Exercise and Pregnancy Laboratory, School of Kinesiology, The University of Western Ontario, London, ON, Canada N6A 3K7. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Obesity / etiology, prevention & control*
Practice Guidelines as Topic
Prenatal Care / methods*
Prenatal Exposure Delayed Effects / etiology, prevention & control*
Journal ID (nlm-ta): J Pregnancy
Journal ID (iso-abbrev): J Pregnancy
Journal ID (publisher-id): JP
Publisher: Hindawi Publishing Corporation
Copyright © 2012 S.-M. Ruchat and M. F. Mottola.
Received Day: 22 Month: 8 Year: 2012
Accepted Day: 4 Month: 10 Year: 2012
Print publication date: Year: 2012
Electronic publication date: Day: 17 Month: 12 Year: 2012
Volume: 2012E-location ID: 470247
PubMed Id: 23316363
|Preventing Long-Term Risk of Obesity for Two Generations: Prenatal Physical Activity Is Part of the Puzzle|
|Michelle F. Mottola123|
1R. Samuel McLaughlin Foundation Exercise and Pregnancy Laboratory, School of Kinesiology, The University of Western Ontario, London, ON, Canada N6A 3K7
2Department of Anatomy and Cell Biology, The University of Western Ontario, London, ON, Canada N6A 3K7
3Children's Health Research Institute, The University of Western Ontario, London, ON, Canada N6A 3K7
|Correspondence: *Stephanie-May Ruchat: email@example.com
[other] Academic Editor: Riitta Luoto
There has been a significant increase over the past few decades in the prevalence of maternal overweight (body mass index, BMI ≥ 25 kg/m2) and obesity (BMI ≥ 30 kg/m2). In the United States, data from the “Pregnancy Risk Assessment Monitoring System” in nine states indicated that pre-pregnancy obesity increased from 13% to 22% between 1993 and 2002 . Worldwide population estimates of pre-pregnancy overweight is approximately 34% [2, 3] and that of pre-pregnancy obesity is 25% . Women who enter pregnancy either normal weight or overweight/obese are at an increased risk of developing obesity or increasing BMI categories because of excessive gestational weight gain (GWG).
Excessive GWG has been associated with short- and long-term adverse maternal and infant outcomes . Large weight gain has been linked to postpartum weight retention, which in turn has been associated with long-term risk of maternal obesity [6–11]. Excessive GWG has also been associated with adverse infant outcomes, such as an increased risk of being heavier and fatter at birth [8, 12–15], which increases the infant's risk of becoming overweight/obese later in life [8, 13, 16, 17]. These findings suggest that influences occurring very early in life are contributing to the obesity onset. The promotion of healthy weight gain during pregnancy is therefore of paramount importance to reduce the risk of long-term obesity and associated comorbidities in both the mother and infant.
To optimize both maternal and infant outcomes, recommendations regarding healthy weight gain have been developed. The Institute of Medicine (IOM) published in 2009 a revision of the 1990 guidelines for how much weight a woman should gain during pregnancy  (Table 1). Using the 1990 IOM recommendations, it has been reported that up to 40% of normal weight women and 60% of overweight/obese women gained excessive weight during pregnancy [11, 13, 18]. However, a study that quantified how the 2009 revisions of the 1990 IOM GWG guidelines changed BMI-specific GWG adherence categories showed that 17.1% of 1990 appropriate weight gaining women would now be classified as excessive gainers, given the new guidelines . Health care providers must therefore determine the women's pre-pregnancy BMI and provide BMI-specific GWG recommendations in accordance with current guidelines, before pregnancy if possible. Further, the importance of healthy weight gain and healthy lifestyle habits to optimize pregnancy outcomes should also be emphasized throughout pregnancy.
Research over the past 25 years has demonstrated that healthy women with low-risk pregnancies can safely participate in physical activities without affecting fetal growth and development [20–23]. In fact, maternal physical activity has been identified as an important component of a healthy pregnancy and is beneficial to the mother and fetus [24, 25]. A sedentary lifestyle, on the other hand, may put the mother and fetus at risk for diseases through altered maternal pregnancy adaptations, such as excessive GWG, gestational diabetes, or gestational hypertension [24, 25]. Observational studies showed that physical activity during pregnancy reduces the risk of glucose intolerance, gestational diabetes [26–29], and excessive GWG [30, 31].
Active promotion of physical activity for pregnant women is strongly recommended in the absence of either medical or obstetric contraindications by professional organizations [23, 32, 33]. The joint Society of Obstetricians and Gynaecologists of Canada (SOGC) and Canadian Society for Exercise Physiology (CSEP) Clinical Practice Guidelines provide detailed recommendations about the frequency, intensity, time, and type of exercise, following the FITT principle for exercise prescription . Low risk medically pre-screened pregnant women should exercise 3 to 4 times per week, starting with 15 minutes of aerobic activity at a specific target heart rate intensity based on age and increase time slowly to a maximum of 30 minutes per exercise session. All aerobic activity should be preceded by 10 to 15 minutes of warm-up and followed by 10 to 15 minutes of cool-down. Appropriate exercise intensity may be monitored by using target heart-rate zones, the Borg-scale (rating of perceived exertion, RPE), or the “talk test” . Heart-rate zones that are provided in the guidelines correspond to moderate-intensity exercise (i.e., 60–80% of maximal aerobic capacity, VO2max) .
The recent opinion statement from the SOGC  on obesity during pregnancy strongly suggests that regular exercise during pregnancy may help to reduce the risk of medical complications associated with maternal obesity. Overweight and obese women can participate in exercise, if they have no contraindications to being physically active. They should therefore be medically pre-screened and consult their health care provider before engaging in an exercise program. Target heart rate zones developed for normal weight pregnant women  may be too difficult for overweight and obese women to obtain. Target heart rate zones for these women were thus developed and validated at a much lower intensity but high enough to achieve aerobic benefits . The American College of Sports Medicine (ACSM) suggested that previously sedentary overweight and obese pregnant women should initiate an aerobic exercise program at an intensity equivalent to 20% to 39% of reserve aerobic capacity (VO2 reserve) . The developed and validated target heart rate zones based on age are 102 to 124 beats per minute (bpm) for overweight and obese women 20 to 29 years of age and 101 to 120 bpm for those aged 30 to 39 years .
Although maternal physical activity has clear health benefits on pregnancy outcomes and is strongly recommended by professional organizations, a large proportion of women do not meet the recommendations for physical activity during pregnancy, based on information collected by interviews or questionnaires [37–40]. Similarly, studies using pedometers to assess the level of physical activity during pregnancy found that many women have sedentary to low physical activity levels during pregnancy and that the levels of activity declined as their pregnancy progressed [41, 42]. Previous studies conducted in our laboratory showed that overweight and obese pregnant women are mostly inactive, accumulating 6,100 ± 1,700 steps per day [43, 44]. However, when a 40-min structured walk (4,300 ± 680 steps per 40-min session) was added to their usual daily activities, these women were taking 10,000 steps or more [43, 44]. As walking is the most reported activity during pregnancy [37–39, 45], providing step-count goals may encourage pregnant women to be more active. The recommendation would be to add 3,000–4,000 steps in a 30–40-min walk (moderate-intensity) to the usual number of daily steps.
Taken together, these findings showed that a large proportion of women are physically inactive during pregnancy. This may be contributing to excessive GWG, high infant weight at birth, and long-term obesity risk in both the mother and child. Pregnancy may be a teachable time when women are motivated to adopt healthy behaviors and may therefore be the perfect opportunity to introduce lifestyle modification strategies promoting physical activity and healthy eating habits in order to achieve a healthy weight gain and pregnancy outcomes.
Several systematic reviews and meta-analyses assessing the effect of prenatal lifestyle interventions on GWG have been published in 2010–2012 [46–54] and their conclusions were that prenatal lifestyle interventions had a modest effect on the decrease in GWG. However, these papers included only randomised control trials, considered mean GWG as the main outcome, discussed only briefly the adherence to the IOM GWG guidelines and if so, did not differentiate findings between the 1990 and 2009 IOM recommendations. Furthermore, few of these reviews discuss the effect that prenatal interventions may have on the prevention of infant high birth weight and none on the prevention of maternal weight retention after delivery, which we believe to be extremely important in the context of the prevention of obesity in the current and next generations.
The objective of this integrative review was therefore to provide a comprehensive overview of prenatal physical activity interventions, alone or in combination with a nutritional intervention, whose main objective was to decrease mean GWG and/or prevent excessive GWG and to raise methodological issues and relevant points to discuss in order to highlight the effective/missing aspects of the reviewed interventions. Further, our objective was also to address important issues, such as whether preventing excessive GWG decreases the incidence of infant high birth weight, or prevents postpartum weight retention. Searches of the PubMed database were performed using the following keywords: “exercise" OR “physical activity" OR “intervention" OR “lifestyle" AND “pregnant" AND “weight gain". Relevant references in the literature obtained were further reviewed to identify additional studies on this topic. All types of intervention (randomised controlled trials, historical cohort, single-arm study) published in English were considered. Studies including gestational diabetic women were excluded. This review includes references published between January 2000 and July 2012.
Using the above mentioned keywords for searches of the PubMed database, 256 studies were detected. After applying the inclusion/exclusion criteria, 16 studies remained. An additional 3 studies were identified from the literature obtained. Among the intervention studies that combined physical activity, nutrition and recommendations regarding healthy GWG (Table 2), 9/13 (69%) were successful at decreasing mean GWG and/or preventing excessive GWG based on the 1990 (Table 2(a)) or 2009 (Table 2(b)) IOM guidelines [44, 55–62] and 4/13 (31%) were unsuccessful [63–66]. Among intervention studies that included a physical activity component alone (Table 3), 2/6 (33%) were only partially successful at reducing mean GWG and/or preventing excessive GWG based on the IOM 1990 (Table 3(a)) or 2009 (Table 3(b)) guidelines [67, 68] and 4/6 (67%) were unsuccessful [69–72].
Asbee at al.  (Table 2(a)) examined the effect of a prenatal intervention on GWG in women of various pre-pregnancy BMI categories (normal weight, overweight, and obese women). This randomised controlled trial (RCT) included detailed recommendations regarding dietary intake, physical activity, and appropriate GWG based on the women's pre-pregnancy BMI. The authors found lower GWG in the intervention group (16.2 ± 7.0 kg) compared to the control group (13.0 ± 5.7, P = 0.01), regardless of BMI status. Although the participants received specific recommendations about dietary intake and physical activity, compliance to these recommendations was not reported. In addition, no information was given regarding physical activity levels and eating habits of the control group. Two other successful interventions included only women who were overweight and/or obese prior to pregnancy. Shirazian et al.  (Table 2(b)) conducted a prenatal intervention that included six seminars and one-on-one counseling sessions (n ≥ 5) aimed at promoting healthy eating and encouraging walking (food diaries and pedometers were provided to the participants) and educating the women on obesity during pregnancy. The intervention group gained less weight than the control group (8.1 ± 7.4 kg versus 15.4 ± 7.5 kg, resp.; P = 0.003). Unfortunately, eating and physical activity habits of the women during the intervention were not reported, although the participants received tools (diaries and pedometers) to monitor their daily dietary intake and physical activity levels. Further, physical activity levels and eating habits of the control group were not reported. Finally, the study of Nascimento et al.  (Table 3(b)) included weekly supervised aerobic dance classes of moderate-intensity, combined with recommendations about weekly physical activity level and healthy GWG. The authors reported lower mean GWG in the intervention group (10.0 ± 1.7 kg) compared with the control group (16.4 ± 3.9 kg, P = 0.001) but only in overweight women (17.5% of the sample) . Sixty-three percent of the women were compliant with the exercise intervention and accumulated a mean of 80 ± 49 minutes of walking every week and 57 ± 22 minutes of exercise from the study protocol. However, no information was provided regarding physical activity levels in overweight and obese women separately. Moreover, the authors did not report physical activity levels for the control group.
Taken together, although these 3 studies were successful at reducing mean GWG, none of them produced statistically significant differences in adherence to IOM recommendations, based on the 1990  or 2009 [57, 68] guidelines.
Studies Using the 1990 IOM Guidelines
Polley et al.  (Table 2(a)) conducted a behavioral intervention with stepped care (increasing one-on-one care if needed) in low-income women of various pre-pregnancy BMI categories (normal weight, overweight, and obese women). The intervention group received education about weight gain, healthy eating and exercise, and individual graphs of their weight gain. The intervention was successful only among normal weight women (55% of the sample), with more women not exceeding the IOM guidelines in the intervention versus control group (67% versus 42%, resp.; P < 0.05) . Changes in dietary intake and exercise expenditure were assessed by questionnaires pre- and post-intervention and showed that normal weight women in the intervention group decreased their fat intake whereas no changes were found in normal weight women in the control group. Regarding physical activity levels, no changes were found in any of the groups . A larger study, based on a clinical component and a by-mail education program targeting healthy eating, physical activity and GWG, with an emphasis on self-monitoring, was successful but only in women of low income (41% of the sample)  (Table 2(a)). Among women of normal weight, 71% of those who participated in the intervention did not exceed the IOM guidelines compared to only 55% (P = 0.05) of the historical cohort. Among the overweight women, 56% of those in the intervention group did not gain excessively compared to only 28% (P = 0.04) of the historical cohort. Mean GWG, as well as nutrition and physical activity habits of these low-income women were not reported. Finally, Phelan et al.  (Table 2(a)) examined the effect of a low-intensity, partially mail-based behavioral intervention targeting dietary intake, physical activity, and weight gain monitoring. The authors found that their intervention was successful but only in women of normal weight prior to pregnancy, with 60% of the women who participated in the intervention not gaining excessively compared with only 48% of those receiving standard prenatal care (P = 0.003). Although the participants received food records and pedometers, nutrition and physical activity habits of the women during the intervention were not reported. Similarly, information regarding lifestyle habits of the control group was not reported.
Studies Using the 2009 IOM Guidelines
Hui et al.  (Table 2(b)) conducted an intervention that combined personalized dietary counseling, weekly supervised exercise sessions and home-based exercises (VHS and DVD). Women of different pre-pregnancy BMI categories were included in the study. Results showed that 65% of the women who followed the intervention did not gain above the 2009 IOM guidelines compared with only 45% of those in the control group (P = 0.008). Only 56% of the women completed a 3-day food intake record at baseline and 2 months after enrolment and the results showed lower energy and fat intake in the intervention group compared to the control group in response to the intervention. Further, 94% of the women completed physical activity questionnaires and the results showed that women in the intervention group increased their physical activity levels and were active more than twice/week for more than 20 minutes/session 2 months after enrolment. No changes in physical activity levels were found in the control group. All women in the intervention group self-reported home exercise for 3–5 times/week during the study.
Studies Using the 1990 IOM Guidelines
Mottola et al.  (Table 2(a)) used a Nutrition and Exercise Lifestyle Intervention Program (NELIP) for overweight and obese pregnant women. This single-arm intervention included a personalized meal plan combined with a supervised walking program of mild-intensity 3 to 4 times/week. This intervention was highly successful, with 80% of the women not exceeding recommended GWG while on NELIP. Mean GWG during the intervention was 6.8 ± 4.1 kg (0.38 ± 0.2 kg/week) . During the intervention, the women walked 2.84 ± 0.87 times per week and dietary intake assessments showed a significant decrease in daily intake of total energy (from 2,228.0 ± 474.6 to 1,900.2 ± 343 kcal) and carbohydrate (from 318.5 ± 155.1 to 259.1 ± 93.9 g) and an increase in the percent of daily energy from protein (16.9% ± 2.4% to 18.4% ± 2.3%).
Studies Using the 2009 IOM Guidelines
Claesson et al.  (Table 3(b)) examined the effect of an intervention that included only women who were obese prior to pregnancy. The cornerstone in the intervention was a motivational interview/talk in early pregnancy, focusing on behavior change. During the intervention, the women were invited to a 30-minute individual session every week for motivational talks and weight gain control. Further, the women were invited to attend aqua aerobic classes 1-2 times/week. Women in the intervention group gained less weight than those in the control group (8.7 ± 5.5 kg versus 11.3 ± 5.8, resp., P < 0.001) and were more likely to gain less than 7.0 kg (study goal) (36% versus 21%, resp., P = 0.003) . Behavior changes in response to the intervention were not reported, nor attendance for the aqua aerobic classes. Similarly, no information was given regarding the lifestyle habits of the control group. The intervention of Vinter et al.  (Table 2(b)) included personalized dietary counseling provided on 4 occasions during the study, supervised exercise sessions offered once per week, with free access to a fitness center for the duration of the study, and 4–6 group sessions given to improve participants' integration of physical activities in pregnancy and daily life. Mean weight gain was 7.0 kg (4.7–10.6 kg) in the intervention group and 8.6 kg (5.7–11.5 kg) in the control group (P = 0.01) . Although more women in the intervention group versus control group did not exceed the 2009 IOM recommendations, the difference was statistically not significant (65% versus 53%, resp., P = 0.058). Compliance with the nutrition counseling sessions was very good, with 92% of the women having completed all 4 nutrition counseling sessions. Eighty-five percent of the women in the intervention group and 21% of those in the control group reported that their participation in the study resulted in more healthy eating habits. However, no information regarding changes in dietary intake of the women was provided by the authors. Attendance for physical activity was more difficult to maintain, with only 56% of the women having attended the aerobic classes for at least half of the lessons. Seventy-eight percent of the women in the intervention group versus 65% of those in the control group engaged in leisure time physical activities during pregnancy. However, the frequency, duration, and intensity of these activities were not reported. Finally, Haakstad et Bø  (Table 2(a)) investigated the effect of a 12-week exercise program in women of different pre-pregnancy BMI categories (75% were of normal weight). The program consisted of 60 minutes of supervised aerobic dance performed at least twice/week. The women were asked to exercise 30 minutes/day on the other days of the week. The intervention was found to be effective only in women who attended 2 dance classes per week (27% of the exercising group), with a mean weight gain of 11.0 ± 2.0 kg in the exercising women and 13.0 ± 4.0 kg in the control women (P = 0.01). All exercising women gained within the recommendations compared to 62% of the control women (P = 0.006).
A large number of intervention studies were unfortunately not successful at reducing mean GWG and preventing excessive GWG based on the IOM guidelines.
Studies Using the 1990 IOM Guidelines
Gray-Donald et al.  (Table 2(a)) developed a community-based intervention for the Aboriginal Cree population, based on the social learning theory. Components of this intervention were pamphlets about nutritional choices, supermarket tours and cooking demonstrations, exercise and walking group sessions, and individual counseling. The intervention, that included women of different pre-pregnancy BMI categories (mean BMI of 30.0 ± 6.5 kg/m2), had no effect on total maternal weight gain and did not prevent excessive GWG based on IOM guidelines. Eating and physical activity habits did not improve. In fact, self-reported sedentary behaviors were significantly higher in the intervention group (61%) compared with the control group (23%) . Guelinckx et al.  (Table 2(a)) examined the effect of an intervention study that was based on a brochure (passive intervention) or on active education (active intervention) about GWG, dietary habits and physical activity in women who were obese prior to pregnancy. Although improvements in dietary habits were observed in both intervention groups, both interventions were unsuccessful at reducing mean GWG and preventing excessive GWG. Physical activity levels were similar in all three groups and decreased significantly throughout pregnancy. Finally, Kinnunen et al.  (Table 2(a)) examined the effect of an intervention that included 4 individual counseling sessions on healthy diet and 5 counseling sessions to help increasing leisure-time physical activity (LTPA), and designing an individual activity plan to achieve a healthy GWG. In addition, the participants had the opportunity to join group exercise sessions once a week for 45–60 minutes. The women, who were of various pre-pregnancy BMI categories (75% were of normal weight) exhibited similar GWG (intervention group, 14.6 ± 5.4 kg versus control group, 14.3 ± 4.1 kg, resp.). Surprisingly, the authors reported a trend in a higher number of women not exceeding the IOM guidelines in the control group compared to the intervention group (70% versus 54%, P = 0.053). However, the intervention improved dietary habits (increase in the intake of vegetables, fruits, and berries) but had no effect on LTPA levels.
Studies Using the 2009 IOM Guidelines
Lindholm et al.  (Table 2(b)) conducted a single-arm intervention for obese women who were invited to an initial individual consultation with a dietician and then to meet with a midwife once every two weeks and to attend 2 group-support sessions. In addition, the intervention included water aerobic classes once per week and the women were asked to exercise 30 minutes/day on other weekdays. Excessive GWG (i.e., >6.0 kg) was prevented in only 56% of the women, with a mean GWG of 6.9 ± 6.4 kg. No information was given regarding improvements in eating and physical activity habits of the women in response to the intervention. Further, attendance to the water aerobic classes was not reported. Finally, 3 studies that included only an exercise intervention were found to be unsuccessful. Barakat et al. [69, 72] (Table 3(b)) published two studies examining the effect of a supervised exercise program performed 3 times/week for 35–40 minutes/session, one focusing on light resistance and toning exercises and the other on aerobic exercises (1/week) and aquatic activities (2/week). Both interventions included women of different pre-pregnancy BMI categories (mean BMI in the normal range). Although adherence to the exercise program was >85%, similar GWG was found in the intervention and control groups. No information was given regarding whether the intervention was successful at preventing excessive GWG based on the 2009 IOM guidelines. Similarly, a supervised water aerobic exercise program of moderate intensity performed 3 times/week for 50 minutes/session had no effect on GWG in sedentary pregnant women of different pre-pregnancy BMI categories  (Table 3). The women participated in a mean of 25 exercise sessions during this 15-week intervention and GWG was similar in the intervention and control groups (14.3 ± 2.1 kg and 15.1 ± 1.6 kg, resp.). Adherence to IOM guidelines was not reported by the authors. Finally, Yeo  (Table 3(a)) compared the effect of a supervised walking program to a stretching program on preeclampsia risk factors, including excessive GWG, in women of different BMI categories prior to pregnancy (81% were obese). The intervention consisted of 40 minutes of stretching or moderate-intensity walking, 5 times/week. Mean GWG was similar in both groups (15.4 ± 5.9 kg in the women who walked and 15.9 ± 6.8 kg in the stretching women), although the walkers tracked more daily steps compared to the stretching group, with an average of 7, 790 ± 3, 890 and 5, 355 ± 3, 044 steps per day, respectively (P = 0.0002). Even if the step difference between the groups was statistically significant, a difference of approximately 2,500 steps per day may not have been enough to impact on GWG. Noteworthy, 2,500 steps is equivalent to approximately 25 min of moderate-intensity walking, implying that the women were not compliant with the exercise program recommending 40 min of moderate-intensity walking.
Based on the studies presented above, it appears that prenatal lifestyle interventions promoting healthy eating and physical activity habits were more successful at decreasing mean GWG and/or preventing excessive GWG compared to those including an exercise component alone (69% versus 33%). This suggests that the same principle may apply to the prevention of excessive GWG as in weight loss: the major component is in dietary changes and the role of physical activity is to support and maintain these achievements .
However, there are still a large number of prenatal lifestyle interventions that were unsuccessful and it is important to discuss the factors that may explain their ineffectiveness in order to design future successful prenatal lifestyle interventions. These factors may be numerous and include characteristics of the women (parity, socioeconomic status, maternal pre-pregnancy BMI, pre-pregnancy physical fitness levels, pre-pregnancy lifestyle habits), the design of the intervention, the gestational age at which the intervention was initiated, the components of the intervention (nutrition, physical activity, behavioral change), the frequency and intensity of physical activity, the type of intervention (i.e., phone-based, mail-based, or supervised intervention), the frequency of the interaction with the women, the contexts or providers of counseling, and, of course, compliance with the intervention.
There is good evidence to suggest that pre-pregnancy BMI is an important factor influencing the success of an intervention and that it should be taken into consideration when designing a prenatal lifestyle intervention. For example, overweight and obese pregnant women likely had unhealthy eating habits and a sedentary lifestyle before becoming pregnant. Asking them to make behavioral changes while participating in a prenatal lifestyle intervention may be challenging. Moreover, they may have body weight issues and low self-esteem. Because of these factors, overweight and obese pregnant women may need more support and encouragement during an intervention to be able to overcome the barriers they may face in order to improve their lifestyle habits and be successful in limiting their weight gain. Accordingly, intervention studies that included overweight and obese women and were successful at reducing mean GWG and preventing excessive GWG were based on frequent individualized nutrition counseling sessions and discussions regarding healthy weight gain throughout pregnancy, combined with supervised exercise sessions [44, 56, 62]. On the other hand, intervention studies based only on written or oral recommendations regarding healthy lifestyle habits during pregnancy and of less frequent interactions were unsuccessful at reducing mean GWG or preventing excessive GWG in overweight and obese women [59, 65]. The way of approaching behavioral change is also of paramount importance, especially in overweight and obese women. Only few prenatal lifestyle interventions included any theoretical background as a basis for behavioral change. However, we may speculate that interventions based on frequent interactions with the participants and discussions regarding healthy weight gain included behavioral change objectives, which may have contributed to the success of these interventions. The background of the providers of counseling may also have influenced the success of the intervention. Counseling provided by the same team of healthcare professionals throughout the intervention (nurse, midwife, dietician, kinesiologist, or psychologist) may have had a stronger impact on helping the women to improve their lifestyle habits and be successful in limiting their weight gain, emphasizing a team approach.
Another factor that may have contributed to the mixed results of prenatal lifestyle interventions may be the use of the 1990 versus 2009 IOM GWG guidelines, although we cannot draw conclusions as to whether studies using the 1990 or 2009 IOM guidelines were more likely to be successful at preventing excessive GWG. However, with the increased prevalence of maternal obesity and the new GWG guidelines that are more restrictive, especially for obese women, we may expected that upcoming studies will have to provide more interactive and frequent counseling sessions to be successful at preventing excessive GWG in obese women.
Finally, an important methodological issue that was identified in several prenatal lifestyle interventions presented above is that although they all included a physical activity component, combined or not with nutritional advice, they did not assess dietary intake and physical activity levels of the participants pre- and post-intervention. Similarly, some interventions provided food diaries and pedometers to the participants in order to encourage them to monitor their daily dietary intake and physical activity levels but the data collected using these tools were not reported by the authors. This is important missing information because researchers need to identify from previous successful interventions what contributed to their success in order to design future successful prenatal lifestyle interventions. Consequently, it is highly important that researchers document the important/effective aspects of their intervention by examining whether the participants were compliant with the recommendations given during the intervention and whether they had modified eating and/or physical activity habits. Further, it is important to examine eating and/or physical activity habits of the control group. The few authors who reported data regarding the impact of their intervention on changes in nutrition and physical activity habits of the participants have found that decreasing fat intake [58, 60], decreasing carbohydrate intake while increasing protein consumption , and increasing physical activity levels to meet physical activity recommendations during pregnancy [44, 60, 67, 68] helped to achieve a healthy GWG.
However, compliance is always difficult to interpret and the authors should report as much information regarding compliance as possible. For example, if compliance with physical activity recommendations is defined as being active 3 times per week, the authors should not only report the mean number of weekly exercise sessions performed by the women but also the percentage of women having been active 3 times per week. In the case where there is few but exceptionally well-adhered women who were active 6 times per week, these women will pull the group average up. The reader will then consider that the intervention was effective because all women were compliant with physical activity recommendations. In fact, the few but exceptionally well-adhered women were mostly responsible for the positive results. However, compliance with the physical activity component of a prenatal lifestyle intervention was found to be a major problem. Factors such as concerns for the safety of the baby, physical limitations, and lack of energy, motivation, or resources may contribute to the low compliance with the physical activity program/recommendations. The inclusion of supervised exercise sessions may help to favor compliance with the physical activity component of the intervention and achievement of healthy weight gain. It would allow frequent interactions with the women during which physical activity-related behavior change objectives may be provided and emphasis put on the safety and health benefit of physical activity during pregnancy.
Taken together, differences in the characteristics of the women, the nutritional, physical activity, and behavioral change approaches used make the comparison of different interventions difficult and the identification of the most effective ways to prevent GWG challenging. Further research is needed to identify the effective aspects of prenatal lifestyle interventions, especially for overweight and obese women, in order to support the current evidence suggesting that prenatal lifestyle interventions may play an important role in the prevention of excessive GWG.
Although the prevention of excessive GWG is important to decrease the incidence of high infant birth weight, 4/19 (21%) of the intervention studies did not report infant birth weight. Among the intervention studies that were successful in decreasing mean GWG or preventing excessive GWG based on the IOM recommendations, two studies did not report infant measurements at birth [55, 67] and seven reported no differences in infant birth weight or in the incidence of low (<2,500 g) or high (>4,000 g) birth weight between the intervention and control groups [56–61, 68]. Only two studies showed a significant effect of limiting GWG on infant weight at birth. Mottola et al.  (Table 2(a)) reported that in the overweight women, a lower percentage of babies born weighing between 4,000 g and 4,500 g was found in the intervention group compared to the historical control cohort (3.2% versus 18%, resp.; P = 0.048). However, similar overall mean birth weight was found between the intervention group (3, 590 ± 500 g) and the historical control cohort (3, 560 ± 600 g; P > 0.05). Also, no babies born to the NELIP women weighed less than 2,500 g, whereas 3.5% of the babies born to the historical control cohort were in this weight category. Conversely, Vinter et al.  (Table 2(b)) surprisingly found higher birth weights in the intervention group (3,742 g) compared to the control group (3,593 g; P = 0.039), with a trend in higher frequency of high birth weight babies (>4,000 g) in the intervention group compared to the control group (32% versus 25%; P = 0.07).
Based on these prenatal lifestyle intervention studies, conclusions suggesting that decreasing GWG or preventing excessive GWG may be linked to lower incidence of high birth weight cannot be drawn, with the exception of one study . Noteworthy, the main outcome of the prenatal lifestyle intervention studies presented above was preventing excessive GWG, with secondary outcomes being preventing high infant birth weight and pregnancy complications. Thus, it is likely that these studies were underpowered to find a significant effect on these outcomes. Future larger and well-controlled intervention studies are therefore warranted to examine the effect of the promotion of healthy lifestyle habits and adequate GWG on newborn weight.
Moreover, future studies should assess body composition of the neonates. First, even if infant weight at birth is similar between the intervention and control groups, differences in body fat distribution might exist and have a long-term impact on the metabolic health of the infant. Second, if a higher birth weight is observed, it is highly important to evaluate whether this is due to higher lean mass or fat mass. Vinter et al. , who found a higher infant weight at birth in the intervention group compared to the control group, mentioned the absence of information regarding body composition of the neonates as a limitation of their study. They also suggested that their findings may be explained by the stimulation of placenta development in response to maternal exercise, which has been previously reported . Another explanation may be the time-specific effect of exercise on fetal growth, as discussed in a recent review paper . Beginning an exercise program in early pregnancy (i.e., first trimester) has been reported to have a stimulatory effect on placenta growth and function, which may increase infant birth weight . Although this may be a beneficial adaptation in lean and physically active women, it may have a less desirable effect of promoting excess fetal growth in overweight/obese women. Interestingly, the intervention of Vinter et al.  started early in pregnancy (10–14 weeks) and the data support this time-specific effect of exercise on fetal growth. Initiating an exercise program for overweight/obese women during the second trimester of pregnancy may be more beneficial in preventing excess fetal growth, as shown by the study of Mottola et al. .
The timing of excessive GWG during pregnancy also deserves more attention. Indeed, excessive GWG that occurs early in pregnancy may not have the same influence on fetal growth and infant weight at birth compared to excessive GWG occurring later in pregnancy. For example, excessive GWG, especially during the first trimester of pregnancy, has been found to be associated with an increased risk of gestational diabetes [76, 77], suggesting that timing of excessive GWG may be related to different patterns of metabolic change affecting glucose metabolism regulation as well as fetal growth.
Finally, it is important to consider that even if prenatal lifestyle interventions were successful at limiting GWG or preventing excessive GWG but had no effect on infant outcome at birth, there still may be a beneficial effect on the long-term health of the infant. As suggested by the fetal programming (Barker's) hypothesis , the prenatal period is a unique physiological window in which maternal and fetal adaptations can have major consequences for the long-term health and well-being of the offspring. More research is needed to examine the effect of prenatal lifestyle interventions on the infant weight trajectory during childhood and adulthood. Moreover, although epidemiological studies have suggested that excessive GWG is associated with an increased risk for the infant of becoming overweight/obese later in life [8, 13, 16, 17], the molecular mechanisms through which the exposure to excessive GWG translates into the development of obesity among offspring is currently unknown. Epigenetics (i.e., changes in gene expression) has been suggested as a very likely mechanism. Genes and metabolic pathways showing epigenetic dysregulation in response to the exposure to excessive GWG are likely involved in obesity development among children. The identification of these genes and metabolic pathways is of high interest and may have the potential in the long term to foster the development of improved prevention programs and treatments.
Finally, one of the objectives of preventing excessive GWG is to optimize maternal outcomes, such as preventing maternal weight retention. However, only 7/19 (37%) of the prenatal lifestyle intervention studies followed the women after delivery [44, 56, 58, 59, 61, 64, 67]. Gray-Donald  and Polley et al.  (Table 2(a)) found similar weight retention at the first postnatal visit in women who followed the intervention and in those who were in the control group. Haakstad and Bø  (Table 3(b)) reported lower weight retention at 8–12 weeks postpartum in women who were compliant with the prenatal exercise program compared to those in the control group (0.8 ± 1.7 kg versus 3.3 ± 4.1 kg, resp.; P = 0.001). Similarly, Claesson et al.  (Table 2(b)) found a mean weight retention of −2.15 ± 5.88 kg and 0.75 ± 5.34 kg at 10–12 weeks postpartum in obese women who followed the intervention and in those who received standard prenatal care, respectively (P < 0.001). In addition, Mottola et al.  (Table 2(a)) showed that overweight/obese women who participated in the NELIP retained a mean of 2.2 ± 5.6 kg at 2 months postpartum, with 53% of the women being within 2.0 kg of pre-pregnancy body mass. Phelan et al.  (Table 2(a)) reported that normal weight and overweight/obese women prior to pregnancy who received the intervention were more likely to be at, or below, their preconception weight at 6 months postpartum than women who received standard prenatal care (OR: 2.1; 95% CI: 1.3, 3.5; P = 0.005). Finally, Olson et al.  found that a significantly smaller proportion of intervention group women retained 2.27 kg or more at 1-year postpartum in the low-income and overweight BMI group (25% versus 55%; P = 0.04).
Taken together, these findings support the importance of promoting a healthy lifestyle during pregnancy to reduce postpartum weight retention. However, because only 32% of prenatal lifestyle intervention studies aiming at preventing excessive GWG followed the women into the postpartum period, future studies should include follow-up in their design. Further, studies are also needed to examine whether the promotion of healthy lifestyle habits during pregnancy has a long-lasting effect in both mother and offspring, beyond the postpartum period.
Obesity is reaching epidemic proportions in today's society and women of childbearing age are at an increased risk for developing this disease because of excessive weight gain during pregnancy and weight retention after birth. Further, offspring of women who gained excessively during pregnancy are at an increased risk of becoming overweight and obese in the long term. Promoting a healthy lifestyle during pregnancy and providing recommendations regarding healthy weight gain, especially in overweight and obese women, become therefore increasingly important in the context of the prevention of obesity. Several prenatal lifestyle interventions have been published but due to several issues discussed in this review, it is difficult to make any conclusions about the most effective way to prevent excessive GWG, reduce the incidence of small or large babies and prevent weight retention. However, prenatal interventions combining a nutritional counseling, supervised physical activity sessions, and a behavioral change approach might be the most successful (Table 4). Noteworthy, this review is restricted to studies published in English, which included mainly Caucasian women. It is possible that the most effective way to prevent excessive GWG is different among women of other ethnicities.
Although the role of prenatal physical activity to prevent excessive GWG has been recently questioned, the prevailing literature indicates that women who were compliant with the physical activity program and met the physical activity recommendations were more likely to achieve appropriate GWG and return to their pre-pregnancy body mass after delivery. Consequently, the role of physical activity during pregnancy per se is not the issue. Instead, it is the designs of the physical activity approaches that may not have been adequate for preventing excessive GWG and/or protocols that were not structured to achieve desired compliance. Only few interventions included any theoretical background as a basis for behavioral change and such approach may help to increase compliance with physical activity program/recommendations. Rigorous scientific research, designed to increase compliance of the women, is still required to make an informed decision about the role of physical activity in the prevention of excessive GWG. In addition, research is needed to examine the long-lasting effect of the prevention of excessive GWG on the risk of obesity for the mother and offspring. Finally, investigating the molecular mechanisms through which the exposure to excessive GWG translates into the development of obesity among offspring (i.e., epigenetic factors) may help to better understand the aetiology of obesity and to develop more efficient prevention intervention and treatment.
S. M. Ruchat was supported by a postdoctoral fellowship from the Canadian Diabetes Association. The authors have no conflict of interests that is directly relevant to the content of this paper.
|1.||Kim SY,Dietz PM,England L,Morrow B,Callaghan WM. Trends in pre-pregnancy obesity in nine states, 1993–2003ObesityYear: 20071549869932-s2.0-3424833257917426334|
|2.||Callaway LK,Prins JB,Chang AM,McIntyre HD. The prevalence and impact of overweight and obesity in an Australian obstetrics populationMedical Journal of AustraliaYear: 2006184256592-s2.0-3174444910916411868|
|3.||LaCoursiere DY,Bloebaum L,Duncan JD,Varner MW. Population-based trends and correlates of maternal overweight and obesity, Utah 1991–2001American Journal of Obstetrics and GynecologyYear: 200519238328392-s2.0-1464444232415746679|
|4.||Chu SY,Kim SY,Bish CL. Prepregnancy obesity prevalence in the United States, 2004-2005Maternal and Child Health JournalYear: 20091356146202-s2.0-6834909038818618231|
|5.||IOMWeight Gain during Pregnancy: Reexamining the GuidelinesYear: 2009Washington, DC, USAThe National Academies Press|
|6.||Siega-Riz AM,Herring AH,Carrier K,Evenson KR,Dole N,Deierlein A. Sociodemographic, perinatal, behavioral, and psychosocial predictors of weight retention at 3 and 12 months postpartumObesityYear: 20101810199620032-s2.0-7795714676220035283|
|7.||Siega-Riz AM,Evenson KR,Dole N. Pregnancy-related weight gain—a link to obesity?Nutrition ReviewsYear: 2004627S105S1112-s2.0-404314447215387475|
|8.||Oken E,Kleinman KP,Belfort MB,Hammitt JK,Gillman MW. Associations of gestational weight gain with short- and longer-term maternal and child health outcomesAmerican Journal of EpidemiologyYear: 200917021731802-s2.0-6765112012819439579|
|9.||Rooney BL,Schauberger CW. Excess pregnancy weight gain and long-term obesity: one decade laterObstetrics and GynecologyYear: 200210022452522-s2.0-003633816512151145|
|10.||Gunderson EP,Abrams B,Selvin S. The relative importance of gestational gain and maternal characteristics associated with the risk of becoming overweight after pregnancyInternational Journal of ObesityYear: 20002412166016682-s2.0-003365373811126221|
|11.||Lowell H,Miller DC. Weight gain during pregnancy: adherence to Health Canada’s guidelines.Health Reports/Statistics CanadaYear: 201021231362-s2.0-77956224346|
|12.||Ludwig DS,Currie J. The association between pregnancy weight gain and birthweight: a within-family comparisonThe LancetYear: 201037697459849902-s2.0-77956929653|
|13.||Crozier SR,Inskip HM,Godfrey KM,et al. Weight gain in pregnancy and childhood body composition: findings from the Southampton Women’s SurveyAmerican Journal of Clinical NutritionYear: 2010916174517512-s2.0-7795304568820375187|
|14.||Dietz PM,Callaghan WM,Sharma AJ. High pregnancy weight gain and risk of excessive fetal growthAmerican Journal of Obstetrics and GynecologyYear: 2009201151.e151.e62-s2.0-6764934203619576373|
|15.||Stotland NE,Cheng YW,Hopkins LM,Caughey AB. Gestational weight gain and adverse neonatal outcome among term infantsObstetrics and GynecologyYear: 20061083 I6356432-s2.0-3374834986716946225|
|16.||Schack-Nielsen L,Michaelsen KF,Gamborg M,Mortensen EL,Sørensen TIA. Gestational weight gain in relation to offspring body mass index and obesity from infancy through adulthoodInternational Journal of ObesityYear: 201034167742-s2.0-7424908844319918246|
|17.||Oken E,Taveras EM,Kleinman KP,Rich-Edwards JW,Gillman MW. Gestational weight gain and child adiposity at age 3 yearsAmerican Journal of Obstetrics and GynecologyYear: 20071964322.e1322.e82-s2.0-3394762361217403405|
|18.||Chu SY,Callaghan WM,Bish CL,D’Angelo D. Gestational weight gain by body mass index among US women delivering live births, 2004-2005: fueling future obesityAmerican Journal of Obstetrics and GynecologyYear: 20092003271.e1271.e72-s2.0-6084908793719136091|
|19.||Simas TAM,Liao X,Garrison A,Sullivan GMT,Howard AE,Hardy JR. Impact of updated institute of medicine guidelines on prepregnancy body mass index categorization, gestational weight gain recommendations, and needed counselingJournal of Women’s HealthYear: 20112068378442-s2.0-79959310685|
|20.||Wolfe LA,Ohtake PJ,Mottola MF,McGrath MJ. Physiological interactions between pregnancy and aerobic exercise.Exercise and Sport Sciences ReviewsYear: 1989172953512-s2.0-00243985192676551|
|21.||Lotgering FK,Gilbert RD,Longo LD. Maternal and fetal responses to exercise during pregnancyPhysiological ReviewsYear: 19856511362-s2.0-00219595803880895|
|22.||Wolfe LA,Brenner IK,Mottola MF. Maternal exercise, fetal well-being and pregnancy outcome.Exercise and Sport Sciences ReviewsYear: 1994221451942-s2.0-00283099157925542|
|23.||Davies GAL,Wolfe LA,Mottola MF,MacKinnon C. Joint SOGC/CSEP clinical practice guideline: exercise in pregnancy and the postpartum periodCanadian Journal of Applied PhysiologyYear: 20032833303412-s2.0-004188177712955862|
|24.||Mottola MF. The role of exercise in the prevention and treatment of gestational diabetes mellitusCurrent Diabetes ReportsYear: 2008842993042-s2.0-5634909828918631443|
|25.||Weissgerber TL,Wolfe LA,Davies GA,Mottola MF. Exercise in the prevention and treatment of maternal-fetal disease: a review of the literatureApplied Physiology, Nutrition, and MetabolismYear: 2006316661674|
|26.||Dye TD,Knox KL,Artal R,Aubry RH,Wojtowycz MA. Physical activity, obesity, and diabetes in pregnancyAmerican Journal of EpidemiologyYear: 1997146119619652-s2.0-00307347879400338|
|27.||Gollenberg AL,Pekow P,Bertone-Johnson ER,Freedson PS,Markenson G,Chasan-Taber L. Sedentary behaviors and abnormal glucose tolerance among pregnant latina womenMedicine and Science in Sports and ExerciseYear: 2010426107910852-s2.0-7795253294219997024|
|28.||Dempsey JC,Butler CL,Sorensen TK,et al. A case-control study of maternal recreational physical activity and risk of gestational diabetes mellitusDiabetes Research and Clinical PracticeYear: 20046622032152-s2.0-794423623815533588|
|29.||Liu J,Laditka JN,Mayer-Davis EJ,Pate RR. Does physical activity during pregnancy reduce the risk of gestational diabetes among previously inactive women?BirthYear: 20083531881952-s2.0-5004910887518844644|
|30.||Stuebe AM,Oken E,Gillman MW. Associations of diet and physical activity during pregnancy with risk for excessive gestational weight gainAmerican Journal of Obstetrics and GynecologyYear: 2009201158.e158.e82-s2.0-6764938558919467640|
|31.||Olson CM,Strawderman MS. Modifiable behavioral factors in a biopsychosocial model predict inadequate and excessive gestational weight gainJournal of the American Dietetic AssociationYear: 2003103148542-s2.0-003726392812525793|
|32.||ACOGExercise during pregnancy and the postpartum periodObstetrics and GynecologyYear: 20029917117311777528|
|33.||RCOGExercise in pregnancy RCOG Statement No. 4., 2006.|
|34.||Davies GA. Obesity in pregnancyJournal of Obstetrics and Gynaecology CanadaYear: 201032216517320181319|
|35.||Davenport MH,Charlesworth S,Vanderspank D,Sopper MM,Mottola MF. Development and validation of exercise target heart rate zones for overweight and obese pregnant womenApplied Physiology, Nutrition and MetabolismYear: 20083359849892-s2.0-53649100266|
|36.||ACSMGuidelines for Exercise Testing and Exercise PrescriptionYear: 20057th editionPhiladelphia, Pa, USALippincott Williams & Wilkins|
|37.||Petersen AM,Leet TL,Brownson RC. Correlates of physical activity among pregnant women in the United StatesMedicine and Science in Sports and ExerciseYear: 20053710174817532-s2.0-2764449560716260976|
|38.||Evenson KR,Savitz DA,Huston SL. Leisure-time physical activity among pregnant women in the USPaediatric and Perinatal EpidemiologyYear: 20041864004072-s2.0-914427260715535815|
|39.||Evenson KR,Wen F. National trends in self-reported physical activity and sedentary behaviors among pregnant women: NHANES 1999–2006Preventive MedicineYear: 20105031231282-s2.0-7714918009320053370|
|40.||Borodulin KM,Evenson KR,Wen F,Herring AH,Benson AM. Physical activity patterns during pregnancyMedicine and Science in Sports and ExerciseYear: 20084011190119082-s2.0-5884912013518845974|
|41.||Lindseth G,Vari P. Measuring physical activity during pregnancyWestern Journal of Nursing ResearchYear: 20052767227342-s2.0-2624446286916157944|
|42.||Downs DS,LeMasurier GC,DiNallo JM. Baby steps: pedometer-determined and self-reported leisure-time exercise behaviors of pregnant womenJournal of Physical Activity and HealthYear: 20096163722-s2.0-5814939466419211959|
|43.||Davenport MH,Mottola MF,McManus R,Gratton R. A walking intervention improves capillary glucose control in women with gestational diabetes mellitus: a pilot studyApplied Physiology, Nutrition and MetabolismYear: 20083335115172-s2.0-44349123392|
|44.||Mottola MF,Giroux I,Gratton R,et al. Nutrition and exercise prevent excess weight gain in overweight pregnant womenMedicine and Science in Sports and ExerciseYear: 20104222652722-s2.0-7514912287520083959|
|45.||Mottola MF,Campbell MK. Activity patterns during pregnancyCanadian Journal of Applied PhysiologyYear: 20032846426532-s2.0-004142095012904639|
|46.||Dodd JM,Grivell RM,Crowther CA,Robinson JS. Antenatal interventions for overweight or obese pregnant women: a systematic review of randomised trialsBritish Journal of Obstetrics and GynaecologyYear: 201011711131613262-s2.0-7795650693020353459|
|47.||Gardner B,Wardle J,Poston L,Croker H. Changing diet and physical activity to reduce gestational weight gain: a meta-analysisObesity ReviewsYear: 2011127e602e6202-s2.0-7995924036721521451|
|48.||Ronnberg AK,Nilsson K. Interventions during pregnancy to reduce excessive gestational weight gain: a systematic review assessing current clinical evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) systemBritish Journal of Obstetrics and GynaecologyYear: 201011711132713342-s2.0-7795654266720840691|
|49.||Skouteris H,Hartley-Clark L,McCabe M,et al. Preventing excessive gestational weight gain: a systematic review of interventionsObesity ReviewsYear: 201011117577682-s2.0-7795855753020880128|
|50.||Streuling I,Beyerlein A,Rosenfeld E,Hofmann H,Schulz T,Von Kries R. Physical activity and gestational weight gain: a meta-analysis of intervention trialsBritish Journal of Obstetrics and GynaecologyYear: 201111832782842-s2.0-7865145087521134106|
|51.||Streuling I,Beyerlein A,Von Kries R. Can gestational weight gain be modified by increasing physical activity and diet counseling? A meta-analysis of interventional trialsAmerican Journal of Clinical NutritionYear: 20109246786872-s2.0-7804941856620668049|
|52.||Campbell F,Johnson M,Messina J,Guillaume L,Goyder E. Behavioural interventions for weight management in pregnancy: a systematic review of quantitative and qualitative dataBMC Public HealthYear: 201111, article 4912-s2.0-79959362404|
|53.||Sui Z,Grivell RM,Dodd JM. Antenatal exercise to improve outcomes in overweight or obese women: a systematic reviewActa Obstetricia et Gynecologica ScandinavicaYear: 201291553854522229625|
|54.||Thangaratinam S,Rogozińska E,Jolly K,et al. Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidenceBritish Medical JournalYear: 2012344e2088|
|55.||Asbee SM,Jenkins TR,Butler JR,White J,Elliot M,Rutledge A. Preventing excessive weight gain during pregnancy through dietary and lifestyle counseling: a randomized controlled trialObstetrics and GynecologyYear: 200911323053122-s2.0-6054911653619155899|
|56.||Claesson IM,Sydsjö G,Brynhildsen J,et al. Weight gain restriction for obese pregnant women: a case-control intervention studyBritish Journal of Obstetrics and GynaecologyYear: 2008115144502-s2.0-3674901966717970795|
|57.||Shirazian T,Monteith S,Friedman F,Rebarber A. Lifestyle modification program decreases pregnancy weight gain in obese womenAmerican Journal of PerinatologyYear: 20102754114142-s2.0-7795293063320013602|
|58.||Polley BA,Wing RR,Sims CJ. Randomized controlled trial to prevent excessive weight gain in pregnant womenInternational Journal of ObesityYear: 20022611149415022-s2.0-003686571812439652|
|59.||Phelan S,Phipps MG,Abrams B,Darroch F,Schaffner A,Wing RR. Randomized trial of a behavioral intervention to prevent excessive gestational weight gain: the Fit for delivery studyAmerican Journal of Clinical NutritionYear: 20119347727792-s2.0-7995320391021310836|
|60.||Hui A,Back L,Ludwig S,et al. Lifestyle intervention on diet and exercise reduced excessive gestational weight gain in pregnant women under a randomised controlled trialBritish Journal of Obstetrics and GynaecologyYear: 20121191707722017967|
|61.||Olson CM,Strawderman MS,Reed RG. Efficacy of an intervention to prevent excessive gestational weight gainAmerican Journal of Obstetrics and GynecologyYear: 200419125305362-s2.0-444438039815343232|
|62.||Vinter CA,Jensen DM,Ovesen P,Beck-Nielsen H,Jørgensen JS. The LiP (Lifestyle in Pregnancy) Study: a randomized controlled trial of lifestyle intervention in 360 obese pregnant womenDiabetes CareYear: 201134122502250721972411|
|63.||Kinnunen TI,Pasanen M,Aittasalo M,et al. Preventing excessive weight gain during pregnancy—a controlled trial in primary health careEuropean Journal of Clinical NutritionYear: 20076178848912-s2.0-3444726183717228348|
|64.||Gray-Donald K,Robinson E,Collier A,David K,Renaud L,Rodrigues S. Intervening to reduce weight gain in pregnancy and gestational diabetes mellitus in Cree communities: an evaluationCanadian Medical Association JournalYear: 200016310124712512-s2.0-003464929011107459|
|65.||Guelinckx I,Devlieger R,Mullie P,Vansant G. Effect of lifestyle intervention on dietary habits, physical activity, and gestational weight gain in obese pregnant women: a randomized controlled trialAmerican Journal of Clinical NutritionYear: 20109123733802-s2.0-7564913836819955397|
|66.||Lindholm ES,Norman M,Kilander CP,Altman D. Weight control program for obese pregnant womenActa Obstetricia et Gynecologica ScandinavicaYear: 20108968408432-s2.0-7795290419319961277|
|67.||Haakstad LAH,Bø K. Effect of regular exercise on prevention of excessive weight gain in pregnancy: a randomised controlled trialEuropean Journal of Contraception and Reproductive Health CareYear: 20111621161252-s2.0-7995293113321417561|
|68.||Nascimento SL,Surita FG,Parpinelli MÂ,Siani S,Pinto e Silva JL. The effect of an antenatal physical exercise programme on maternal/perinatal outcomes and quality of life in overweight and obese pregnant women: a randomised clinical trialBritish Journal of Obstetrics and GynaecologyYear: 2011118121455146321895947|
|69.||Barakat R,Lucia A,Ruiz JR. Resistance exercise training during pregnancy and newborn’s birth size: a randomised controlled trialInternational Journal of ObesityYear: 2009339104810572-s2.0-7034916157719636320|
|70.||Cavalcante SR,Cecatti JG,Pereira RI,Baciuk EP,Bernardo AL,Silveira C. Water aerobics II: maternal body composition and perinatal outcomes after a program for low risk pregnant womenReproductive HealthYear: 200961, article 12-s2.0-62449111640|
|71.||Yeo S. Adherence to walking or stretching, and risk of preeclampsia in sedentary pregnant womenResearch in Nursing and HealthYear: 20093243793902-s2.0-6824913130919415672|
|72.||Barakat R,Cordero Y,Coteron J,Luaces M,Montejo R. Exercise during pregnancy improves maternal glucose screen at 24–28 weeks: a randomised controlled trialBritish Journal of Sports MedicineYear: 201246965666121948120|
|73.||Phelan S,Jankovitz K,Hagobian T,Abrams B. Reducing excessive gestational weight gain: lessons from the weight control literature and avenues for future researchWomens HealthYear: 201176641661|
|74.||Clapp JF III. The effects of maternal exercise on fetal oxygenation and feto-placental growthEuropean Journal of Obstetrics & Gynecology and Reproductive BiologyYear: 20031101, supplementS80S8512965094|
|75.||Hopkins SA,Cutfield WS. Exercise in pregnancy: weighing up the long-term impact on the next generationExercise and Sport Sciences ReviewsYear: 20113931201272-s2.0-7995993958121519301|
|76.||Hedderson MM,Gunderson EP,Ferrara A. Gestational weight gain and risk of gestational diabetes mellitusObstetrics and GynecologyYear: 201011535976042-s2.0-7764914766920177292|
|77.||Morisset AS,Tchernof A,Dubé MC,Veillette J,Weisnagel SJ,Robitaille J. Weight gain measures in women with gestational diabetes mellitusJournal of Women’s HealthYear: 20112033753802-s2.0-79952766064|
|78.||Hales CN,Barker DJP. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesisDiabetologiaYear: 19923575956012-s2.0-00267727721644236|
|79.||IOMNutrition During Pregnancy—Part I, Weight GainYear: 1990Washington, DC, USANational Academy Press|
Previous Document: Prevention of preeclampsia.
Next Document: Effects of tobacco smoking in pregnancy on offspring intelligence at the age of 5.