| Preventing heart disease: is treating the high risk sufficient? | |
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MedLine Citation:
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PMID: 3204419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monte Carlo simulation was used to assess the effects of several intervention strategies on coronary heart disease mortality rates in a Finnish and a North American cohort. Lowering total serum cholesterol by 4%, smoking by 15%, and diastolic blood pressure by 3% for the whole cohort would be expected to reduce the incidence of non-fatal myocardial infarction by at least 13% and coronary heart disease deaths by at least 18%. Lowering serum cholesterol by 34%, diastolic blood pressure to 90 mmHg, and reducing smoking by 20% in the subset of the population with all three risk factors in the highest quartile would result in a 6-8% reduction in non-fatal myocardial infarction and a 2-9% reduction in deaths from coronary heart disease in these cohorts. These data demonstrate that in populations with a relatively high incidence of heart disease, treating the entire population will produce larger effects than focusing only on high-risk populations. |
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Authors:
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T E Kottke; L C Gatewood; S C Wu; H A Park |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical epidemiology Volume: 41 ISSN: 0895-4356 ISO Abbreviation: J Clin Epidemiol Publication Date: 1988 |
Date Detail:
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Created Date: 1989-02-09 Completed Date: 1989-02-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8801383 Medline TA: J Clin Epidemiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1083-93 Citation Subset: IM |
Affiliation:
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Department of Medicine, Mayo Clinic, Rochester, MN 55905. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Coronary Disease / prevention & control* Finland Humans Hypercholesterolemia / complications, prevention & control Hypertension / complications, prevention & control Male Middle Aged Monte Carlo Method* Operations Research* Risk Factors Smoking / adverse effects, prevention & control United States |
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