Document Detail

Preventing heart disease: is treating the high risk sufficient?
MedLine Citation:
PMID:  3204419     Owner:  NLM     Status:  MEDLINE    
Monte Carlo simulation was used to assess the effects of several intervention strategies on coronary heart disease mortality rates in a Finnish and a North American cohort. Lowering total serum cholesterol by 4%, smoking by 15%, and diastolic blood pressure by 3% for the whole cohort would be expected to reduce the incidence of non-fatal myocardial infarction by at least 13% and coronary heart disease deaths by at least 18%. Lowering serum cholesterol by 34%, diastolic blood pressure to 90 mmHg, and reducing smoking by 20% in the subset of the population with all three risk factors in the highest quartile would result in a 6-8% reduction in non-fatal myocardial infarction and a 2-9% reduction in deaths from coronary heart disease in these cohorts. These data demonstrate that in populations with a relatively high incidence of heart disease, treating the entire population will produce larger effects than focusing only on high-risk populations.
T E Kottke; L C Gatewood; S C Wu; H A Park
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical epidemiology     Volume:  41     ISSN:  0895-4356     ISO Abbreviation:  J Clin Epidemiol     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8801383     Medline TA:  J Clin Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1083-93     Citation Subset:  IM    
Department of Medicine, Mayo Clinic, Rochester, MN 55905.
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MeSH Terms
Coronary Disease / prevention & control*
Hypercholesterolemia / complications,  prevention & control
Hypertension / complications,  prevention & control
Middle Aged
Monte Carlo Method*
Operations Research*
Risk Factors
Smoking / adverse effects,  prevention & control
United States

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