| Preventing dyslipidemia by Chlorella pyrenoidosa in rats and hamsters after chronic high fat diet treatment. | |
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MedLine Citation:
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PMID: 15850594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of Chlorella pyrenoidosa on serum lipid profiles, after concomitant long-term treatment of high-fat diet (HFD) in rats and hamsters was studied. Wistar rats and Syrian hamsters were fed with or without various concentrations of Chlorella pyrenoidosa contained high-fat diet (CHFD) for 2, 4 and 8 weeks prior to assay of serum lipids. Fasting triglycerides, total cholesterol, and LDL cholesterol as well as HDL cholesterol levels in high-fat diet treated rats and hamster were determined. Results showed that triglycerides, total cholesterol and LDL cholesterol levels in HFD treated rats and hamsters were increased from the normal rodent diet (NRD) treated controls after 2, 4, and 8-week treatments. However, the presence of Chlorella pyrenoidosa in high-fat diets significantly decreased the levels of triglycerides, total cholesterol and LDL cholesterol with comparison to HFD group in rats and hamsters. The total cholesterol/HDL ratios, an indication of occurrence of coronary heart disease, were decreased in all CHFD treated grouped rats and hamsters which suggests administration of Chlorella pyrenoidosa could lower the occurring risk of heart diseases. In conclusion, Chlorella pyrenoidosa has the ability to prevent dyslipidemia in chronic high-fat fed animals and could be potential in use to prevent intestinal absorption of redundant lipid from our daily intake and subsequently to prevent hyperlipidemia as well as atherosclerosis. |
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Authors:
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Jong-Yuh Cherng; Mei-Fen Shih |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 76 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-26 Completed Date: 2005-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 3001-13 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, Chia-Nan University of Pharmacy and Science, 60 Erh-Jen Road, Sec.1, Tainan, 717, Taiwan ROC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chlorella / chemistry* Cricetinae Dietary Fats / administration & dosage* Dietary Supplements* Disease Models, Animal Hyperlipidemias / etiology, metabolism, prevention & control* Lipids / blood Male Mesocricetus Plant Extracts / administration & dosage Rats |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Lipids; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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