| Preventing asthma exacerbations: what are the targets ? | |
| | |
MedLine Citation:
|
PMID: 21440000 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Exacerbations of asthma are the main cause of asthma morbidity. They induce acute respiratory failure, and sometimes death. Two immunological signals acting in synergy are necessary for inducing asthma exacerbations. The first, triggered by allergens and / or unknown agents leads to the chronic Th2 inflammation characteristic of asthma. The second, caused by either viral infection, allergens, pollutants or a combination of these, results in an acute Th1 and Th2 inflammation precipitating symptoms. In both, innate and adaptive immunities are involved, providing a series of potential targets for therapy. Molecules associated to the first, chronic inflammation constitute targets for preventing therapies, when these related to the second, acute signal provide the rationale for curative treatments. Toll like receptors and bronchial epithelial cell-derived cytokines, engaged upstream of inflammation constitute interesting candidates for future treatments. The great heterogeneity of asthma has to be taken into account when considering targets for therapy to identify clusters of responders and non responders, and an integrative system biology approach will be necessary to go further. |
| | |
Authors:
|
Karine Botturi; Marie Langelot; David Lair; Anaïs Pipet; Mallory Pain; Julie Chesne; Dorian Hassoun; Yannick Lacoeuille; Arnaud Cavaillès; Antoine Magnan |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-23 |
Journal Detail:
|
Title: Pharmacology & therapeutics Volume: - ISSN: 1879-016X ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905840 Medline TA: Pharmacol Ther Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2010. Published by Elsevier Inc. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mandatory reporting and improvements in diagnosing Clostridium difficile infection: an incompatible ...
Next Document: Serotonin receptors and heart valve disease - it was meant 2B.