Document Detail

Preventable sudden death in patients receiving angiotensin converting enzyme inhibitors and loop/potassium sparing diuretic combinations.
MedLine Citation:
PMID:  1737674     Owner:  NLM     Status:  MEDLINE    
Angiotensin-converting-enzyme inhibitors are frequently used in conjunction with diuretics in the treatment of congestive cardiac failure. We report two cases in which use of a proprietary combination diuretic containing a loop diuretic and potassium sparing agent with an angiotensin converting enzyme inhibitor was associated with hyperkalaemic cardiac arrest. Successful resuscitation from the arrest permitted elucidation of its mechanism. We believe that this outcome has not previously been reported, and emphasise the importance of electrolyte monitoring in patients receiving angiotensin converting enzyme inhibitors particularly if prescribed in addition to fixed combination proprietary diuretics.
R T Johnston; D P de Bono; C R Nyman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  34     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-19     Completed Date:  1992-03-19     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  213-5     Citation Subset:  IM    
Department of Cardiology, Groby Road Hospital, Leicester, U.K.
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MeSH Terms
Amiloride / adverse effects
Angiotensin-Converting Enzyme Inhibitors / adverse effects*
Diuretics / adverse effects*
Drug Therapy, Combination
Enalapril / adverse effects*
Furosemide / adverse effects
Heart Arrest / etiology*
Hyperkalemia / chemically induced*,  complications
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Diuretics; 2609-46-3/Amiloride; 54-31-9/Furosemide; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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