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The PreventCD Study design: towards new strategies for the prevention of coeliac disease.
MedLine Citation:
PMID:  21389794     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: PreventCD (www.preventcd.com) is a European multicentre study, which studies the influence of infant nutrition, and that of genetic, immunologic and environmental factors, on the risk of developing coeliac disease (CD). The hypothesis is that it is possible to induce tolerance to gluten by introducing small quantities of gluten to infants, preferably while they are still being breast-fed, and that this might also reduce the risk for related autoimmune disorders. AIM: To describe the design of this ongoing European CD research project. METHODS: PreventCD encompasses two study designs and two study populations: (i) a European multicentre study: a prospective, double-blind, randomized dietary-intervention study among infants from families with high risk of CD, and (ii) a Swedish population-based CD screening study among 12-year-olds from the general population, divided into two birth cohorts that differ with respect to infant feeding practices. DISCUSSION: PreventCD is expected to elucidate some of the genetic and immunological mechanisms involved in the process of immune intolerance.
Authors:
Caroline Elisabeth Hogen Esch; Anna Rosén; Renata Auricchio; Jihane Romanos; Anna Chmielewska; Hein Putter; Anneli Ivarsson; Hania Szajewska; Frits Koning; Cisca Wijmenga; Riccardo Troncone; Maria Luisa Mearin
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  22     ISSN:  1473-5687     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-3-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1424-1430     Citation Subset:  -    
Affiliation:
Departments of aPediatric Gastroenterology bMedical Statistics cImmunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden dDepartment of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands eDepartment of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå, Sweden fDepartment of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University 'Federico II', Naples, Italy gDepartment of Pediatrics, The Medical University of Warsaw, Warsaw, Poland.
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