Document Detail


Prevascularization of cardiac patch on the omentum improves its therapeutic outcome.
MedLine Citation:
PMID:  19706385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recent progress made in the bioengineering of cardiac patches offers a new therapeutic modality for regenerating the myocardium after myocardial infarction (MI). We present here a strategy for the engineering of a cardiac patch with mature vasculature by heterotopic transplantation onto the omentum. The patch was constructed by seeding neonatal cardiac cells with a mixture of prosurvival and angiogenic factors into an alginate scaffold capable of factor binding and sustained release. After 48 h in culture, the patch was vascularized for 7 days on the omentum, then explanted and transplanted onto infarcted rat hearts, 7 days after MI induction. When evaluated 28 days later, the vascularized cardiac patch showed structural and electrical integration into host myocardium. Moreover, the vascularized patch induced thicker scars, prevented further dilatation of the chamber and ventricular dysfunction. Thus, our study provides evidence that grafting prevascularized cardiac patch into infarct can improve cardiac function after MI.
Authors:
Tal Dvir; Alon Kedem; Emil Ruvinov; Oren Levy; Inbar Freeman; Natalie Landa; Radka Holbova; Micha S Feinberg; Shani Dror; Yoram Etzion; Jonathan Leor; Smadar Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-24
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  106     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-06     Completed Date:  2009-11-06     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14990-5     Citation Subset:  IM    
Affiliation:
Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel 84105.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Culture Techniques / methods*
Cell Differentiation*
Cells, Cultured
Electrocardiography
Graft Survival
Heart Transplantation / methods*
Male
Microscopy, Electron, Scanning
Myocardial Infarction / physiopathology,  surgery*
Neovascularization, Physiologic
Omentum / blood supply*,  cytology,  surgery*
Rats
Rats, Sprague-Dawley
Tissue Engineering / methods*
Transplantation, Heterotopic
Treatment Outcome
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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