Document Detail


Prevascularisation with endothelial progenitor cells improved restoration of the architectural and functional properties of newly formed bone for bone reconstruction.
MedLine Citation:
PMID:  23288045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of this study was to examine whether the addition of endothelial progenitor cells (EPCs) contributes to restoring the architectural and functional properties of newly formed bone for reconstruction of bone defects.
METHODS: Bone marrow-derived EPCs and mesenchymal stem cells (MSCs) were co-seeded onto demineralized bone matrix (DBM) as a prevascularized tissue-engineered bone (TEB) for the repair of segmental bone defects to evaluate the effects of prevascularization of TEB on ameliorating morphological, haemodynamic and mechanical characteristics.
RESULTS: The restoration of the intraosseous vasculature and medullary cavity was improved markedly compared to the non-prevascularized groups. The blood supply, biomechanical strength, and bone mineral density of the prevascularized group were significantly higher than those of the non-prevascularized groups during bone reconstruction.
CONCLUSIONS: The present study indicates that EPC-dependent prevascularization contributes to bone healing with structural reconstruction and functional recovery and may improve the understanding of correlation between angiogenesis and osteogenesis.
Authors:
Hao Pang; Xue-Hui Wu; Sheng-Long Fu; Fei Luo; Ze-Hua Zhang; Tian-Yong Hou; Zhi-Qiang Li; Zheng-Qi Chang; Bo Yu; Jian-Zhong Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-04
Journal Detail:
Title:  International orthopaedics     Volume:  37     ISSN:  1432-5195     ISO Abbreviation:  Int Orthop     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-28     Completed Date:  2013-10-18     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  753-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanical Phenomena
Bone Density / physiology
Bone Matrix / cytology,  physiology
Bone and Bones / blood supply*,  physiology*
Coculture Techniques
Endothelium, Vascular / cytology*,  physiology
Models, Animal
Neovascularization, Physiologic / physiology*
Osteogenesis / physiology*
Rabbits
Radius / cytology,  physiology
Stem Cells / cytology*,  physiology
Tissue Engineering
Tissue Scaffolds
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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