Document Detail


Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado.
MedLine Citation:
PMID:  17608242     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Vitamin D insufficiency is common in the elderly. However, previous studies have utilized 25-hydroxvvitamin D (25[OH]D) concentrations as low as <16 ng/mL for defining vitamin D insufficiency. Moreover, most of the studies have been conducted in European patients, in certain geographic areas of the United States, or in institutionalized elderly. OBJECTIVE: The goal of this study was to characterize vitamin D concentrations in ambulatory elderly living in metropolitan Denver, Colorado, utilizing 25(OH)D concentrations <32 ng/mL as the definition for vitamin D insufficiency. METHODS: Ambulatory older adults (aged 65-89 years) with clinic visits during December 2005 and January 2006 were enrolled. Serum concentrations of 25(OH)D, parathyroid hormone (PTH), calcium, phosphorus, creatinine, and albumin were measured; height and weight were also measured. Data regarding dietary and over-the-counter vitamin D intake were collected, as well as information on body mass index, history of osteoporosis, osteoporosis treatment, and history of falls and fractures. RESULTS: Eighty patients (mean [SD] age, 77.8 [5.3] years; age range, 66-89 years) completed the study; there were no dropouts. The majority of patients were white (88%) and female (68%). Fifty-nine (74%) were found to have vitamin D insufficiency. Mean total and over-the-counter vitamin D intake was significantly higher in sufficient (P < 0.01) and insufficient (P < 0.05) patients compared with deficient patients, but dietary intake did not differ significantly between groups. The majority of patients who were vitamin D insufficient consumed more than the recommended 400 to 600 IU/d of vitamin D. Obese patients were found to have significantly lower 25(OH)D concentrations (P < 0.001) and higher PTH concentrations (P = 0.04) than nonobese patients. CONCLUSIONS: Vitamin D insufficiency is prevalent in ambulatory, and especially obese, elderly living in Denver, Colorado, despite vitamin D intake consistent with national recommendations. Dietary intake of vitamin D appeared to be unreliable to prevent insufficiency. Based on our results, along with other published data, we feel that national recommendations for vitamin D intake in the elderly should be increased to at least 800 to 1000 IU/d of over-the-counter supplemental cholecalciferol.
Authors:
Sunny A Linnebur; Sheryl F Vondracek; Joseph P Vande Griend; J Mark Ruscin; Michael T McDermott
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of geriatric pharmacotherapy     Volume:  5     ISSN:  1543-5946     ISO Abbreviation:  Am J Geriatr Pharmacother     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-07-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101190325     Medline TA:  Am J Geriatr Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacy, University of Colorado at Denver and Health Sciences Center; Denver, Colorado 80262, USA. sunny.linnebur@uchsc.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Aged, 80 and over
Ambulatory Care
Calcium / blood
Colorado / epidemiology
Creatinine / blood
Cross-Sectional Studies
Diet*
Female
Humans
Male
Nonprescription Drugs
Nutrition Policy
Obesity / complications
Outpatients
Parathyroid Hormone / blood
Phosphorus / blood
Prevalence
Prospective Studies
Risk Factors
Serum Albumin
Vitamin D / administration & dosage,  analogs & derivatives*,  blood,  therapeutic use*
Vitamin D Deficiency / epidemiology*
Vitamins / administration & dosage,  therapeutic use*
Grant Support
ID/Acronym/Agency:
M01RR000051/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Nonprescription Drugs; 0/Parathyroid Hormone; 0/Serum Albumin; 0/Vitamins; 1406-16-2/Vitamin D; 60-27-5/Creatinine; 64719-49-9/25-hydroxyvitamin D; 7440-70-2/Calcium; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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