| Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado. | |
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MedLine Citation:
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PMID: 17608242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vitamin D insufficiency is common in the elderly. However, previous studies have utilized 25-hydroxvvitamin D (25[OH]D) concentrations as low as <16 ng/mL for defining vitamin D insufficiency. Moreover, most of the studies have been conducted in European patients, in certain geographic areas of the United States, or in institutionalized elderly. OBJECTIVE: The goal of this study was to characterize vitamin D concentrations in ambulatory elderly living in metropolitan Denver, Colorado, utilizing 25(OH)D concentrations <32 ng/mL as the definition for vitamin D insufficiency. METHODS: Ambulatory older adults (aged 65-89 years) with clinic visits during December 2005 and January 2006 were enrolled. Serum concentrations of 25(OH)D, parathyroid hormone (PTH), calcium, phosphorus, creatinine, and albumin were measured; height and weight were also measured. Data regarding dietary and over-the-counter vitamin D intake were collected, as well as information on body mass index, history of osteoporosis, osteoporosis treatment, and history of falls and fractures. RESULTS: Eighty patients (mean [SD] age, 77.8 [5.3] years; age range, 66-89 years) completed the study; there were no dropouts. The majority of patients were white (88%) and female (68%). Fifty-nine (74%) were found to have vitamin D insufficiency. Mean total and over-the-counter vitamin D intake was significantly higher in sufficient (P < 0.01) and insufficient (P < 0.05) patients compared with deficient patients, but dietary intake did not differ significantly between groups. The majority of patients who were vitamin D insufficient consumed more than the recommended 400 to 600 IU/d of vitamin D. Obese patients were found to have significantly lower 25(OH)D concentrations (P < 0.001) and higher PTH concentrations (P = 0.04) than nonobese patients. CONCLUSIONS: Vitamin D insufficiency is prevalent in ambulatory, and especially obese, elderly living in Denver, Colorado, despite vitamin D intake consistent with national recommendations. Dietary intake of vitamin D appeared to be unreliable to prevent insufficiency. Based on our results, along with other published data, we feel that national recommendations for vitamin D intake in the elderly should be increased to at least 800 to 1000 IU/d of over-the-counter supplemental cholecalciferol. |
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Authors:
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Sunny A Linnebur; Sheryl F Vondracek; Joseph P Vande Griend; J Mark Ruscin; Michael T McDermott |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of geriatric pharmacotherapy Volume: 5 ISSN: 1543-5946 ISO Abbreviation: Am J Geriatr Pharmacother Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-07-04 Completed Date: 2007-07-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101190325 Medline TA: Am J Geriatr Pharmacother Country: United States |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacy, University of Colorado at Denver and Health Sciences Center; Denver, Colorado 80262, USA. sunny.linnebur@uchsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Ambulatory Care Calcium / blood Colorado / epidemiology Creatinine / blood Cross-Sectional Studies Diet* Female Humans Male Nonprescription Drugs Nutrition Policy Obesity / complications Outpatients Parathyroid Hormone / blood Phosphorus / blood Prevalence Prospective Studies Risk Factors Serum Albumin Vitamin D / administration & dosage, analogs & derivatives*, blood, therapeutic use* Vitamin D Deficiency / epidemiology* Vitamins / administration & dosage, therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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M01RR000051/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nonprescription Drugs; 0/Parathyroid Hormone; 0/Serum Albumin; 0/Vitamins; 1406-16-2/Vitamin D; 60-27-5/Creatinine; 64719-49-9/25-hydroxyvitamin D; 7440-70-2/Calcium; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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