Document Detail


Prevalence of vitamin D deficiency in adult tuberculosis patients at a central hospital in Malawi.
MedLine Citation:
PMID:  21333112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D deficiency (VDD) is associated with impaired mycobacterial immunity and susceptibility to tuberculosis (TB). We measured 25 hydroxy vitamin D levels in 161 adult TB patients at a central hospital in Malawi, of whom 120 (74.5%) had ≤75 nmol/l (hypovitaminosis D), 68 (42%) had ≤50 nmol/l (VDD) and 13.6% of in-patients and 6.8% of out-patients had ≤25 nmol/l (severe VDD). In-patients had lower body mass index (BMI; 19.0 vs. 20.5, P < 0.004), and vitamin D levels were lower in those with BMI < 20. However, on multiple regression analysis in-patient status and BMI were not associated with vitamin D level. We conclude that VDD is common in adult TB patients in Malawi. In this small sample, it was not possible to identify any independent associations of VDD.
Authors:
R Banda; B Mhemedi; T J Allain
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  15     ISSN:  1815-7920     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-21     Completed Date:  2011-06-20     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  408-10     Citation Subset:  IM    
Affiliation:
College of Medicine, University of Malawi, Blantyre, Malawi.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Body Mass Index
Cross-Sectional Studies
Female
Hospitals / statistics & numerical data
Humans
Malawi / epidemiology
Male
Middle Aged
Prevalence
Regression Analysis
Tuberculosis / epidemiology*
Vitamin D / analogs & derivatives*,  blood
Vitamin D Deficiency / complications,  epidemiology*
Young Adult
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections
Comment In:
Int J Tuberc Lung Dis. 2011 Aug;15(8):1133-4   [PMID:  21740682 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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