Document Detail


Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries.
MedLine Citation:
PMID:  23389622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aims to estimate the prevalence of and temporal trends in prenatal antipsychotic medication use within a cohort of pregnant women in the U.S. We identified live born deliveries to women aged 15-45 years in 2001-2007 from 11 U.S. health plans participating in the Medication Exposure in Pregnancy Risk Evaluation Program. We ascertained prenatal exposure to antipsychotics from health plan pharmacy dispensing files, gestational age from linked infant birth certificate files, and ICD-9-CM diagnosis codes from health plan claims files. We calculated the prevalence of prenatal use of atypical and typical antipsychotics according to year of delivery, trimester of pregnancy, and mental health diagnosis. Among 585,615 qualifying deliveries, 4,223 (0.72%) were to women who received an atypical antipsychotic and 548 (0.09%) were to women receiving a typical antipsychotic any time from 60 days before pregnancy through delivery. There was a 2.5-fold increase in atypical antipsychotic use during the study period, from 0.33% (95% confidence interval: 0.29%, 0.37%) in 2001 to 0.82% (0.76%, 0.88%) in 2007, while the use of typical antipsychotics remained stable. Depression was the most common mental health diagnosis among deliveries to women with atypical antipsychotic use (63%), followed by bipolar disorder (43%) and schizophrenia (13%). The number and proportion of pregnancies exposed to atypical antipsychotics has increased dramatically in recent years. Studies are needed to examine the comparative safety and effectiveness of these medications relative to other therapeutic options in pregnancy.
Authors:
Sengwee Toh; Qian Li; T Craig Cheetham; William O Cooper; Robert L Davis; Sascha Dublin; Tarek A Hammad; De-Kun Li; Pamala A Pawloski; Simone P Pinheiro; Marsha A Raebel; Pamela E Scott; David H Smith; William V Bobo; Jean M Lawrence; Inna Dashevsky; Katherine Haffenreffer; Lyndsay A Avalos; Susan E Andrade
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2013-02-07
Journal Detail:
Title:  Archives of women's mental health     Volume:  16     ISSN:  1435-1102     ISO Abbreviation:  Arch Womens Ment Health     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-12     Completed Date:  2013-09-09     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  9815663     Medline TA:  Arch Womens Ment Health     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  149-57     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antipsychotic Agents / therapeutic use*
Drug Utilization / statistics & numerical data,  trends*
Female
Health Care Surveys
Humans
International Classification of Diseases
Middle Aged
Population Surveillance
Pregnancy
Prenatal Care
Prescriptions / statistics & numerical data*
Prevalence
Schizophrenia / drug therapy*,  epidemiology
Socioeconomic Factors
United States / epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
HHSF223200510008C//PHS HHS; HHSF223200510009C//PHS HHS; HHSF223200510012C//PHS HHS; K23 AG028954/AG/NIA NIH HHS; K23 MH087747/MH/NIMH NIH HHS; K23AG028954/AG/NIA NIH HHS; K23MH087747/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antipsychotic Agents
Comments/Corrections

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