Document Detail

Prevalence of transient hyperglycemia and diabetes mellitus in pediatric patients with acute leukemia.
MedLine Citation:
PMID:  24734157     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: The most common malignancy of children is Leukemia, accounting approximately one third of cancer diagnosis. Available data demonstrate improvement in survival of pediatric leukemia, so evaluation of side effects of treatment is very important. This study investigates hyperglycemia and diabetes mellitus prevalence in pediatric patients with acute leukemia.
MATERIALS AND METHODS: This study was performed in children with acute leukemia. At the first admission, demographic data was collected and blood glucose and HbA1c levels were obtained. These tests examined at least two times during six months of follow up. Growth parameters and blood samples were obtained too.
RESULT: Twenty nine patients were examined; three of them (10.3%) had diabetes mellitus and 5patients (17.2%) had transient hyperglycemia.Mean age of the patients was 6.26 years and nineteen Children (63%) were in preschool age. In preschool age children, incidence of hyperglycemia was meaningfully higher than school age children (p= 0.02). 24 of 29 patients (82.7%) were known case of acute lymphoblastic leukemia (ALL) and 5 patients (17.3%) were known case of acute myeloblastic leukemia (AML). No significant difference was found between sex groups. Also underweight was significant risk factor for hyperglycemia.
CONCLUSION: The prevalence of hyperglycemia was in the range of other similar studies in different parts of the world. Underweight and preschool ages were significant predictors of hyperglycemia.
A Banihashem; A Ghasemi; N Ghaemi; N Moazzen; A Amirabadi
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Publication Detail:
Type:  Journal Article     Date:  2014-02-20
Journal Detail:
Title:  Iranian journal of pediatric hematology and oncology     Volume:  4     ISSN:  2008-8892     ISO Abbreviation:  Iran J Ped Hematol Oncol     Publication Date:  2014  
Date Detail:
Created Date:  2014-04-15     Completed Date:  2014-04-15     Revised Date:  2014-04-17    
Medline Journal Info:
Nlm Unique ID:  101571320     Medline TA:  Iran J Ped Hematol Oncol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  -    
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