Document Detail


Prevalence of thyroid peroxidase, thyroglobulin and thyrotropin receptor antibodies in a long-term follow-up of juvenile Graves disease.
MedLine Citation:
PMID:  11092696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To relate the presence of thyroid peroxidase antibodies (TPO ab), thyroglobulin antibodies (Tg ab) and thyrotropin receptor antibodies (TSH-R ab) to the clinical course in a long-term follow-up of patients with juvenile Graves' disease (JGD). DESIGN: Patients with JGD were drawn from a Danish retrospective study and reexamined. RESULTS: A number of 105 patients were reexamined 4-21 years (median 10 years) after diagnosis. Three groups were formed: Gr.1: euthyroid patients with anti-thyroid drug (ATD) cessation more than 12 months before reexamination (n=41). Gr.2: patients still on ATD (n=24). Gr.3: subtotally thyroidectomized patients (n=40). Positive TPO ab titers were found in 75% of the patients. In 13% of the patients the titers were very high: >10,000 U/ml. Positive Tg ab were found in 51%. The prevalence of TPO ab and Tg ab was the lowest in group 3. Stimulating TSH-R ab titers were found in 13%. No patients had blocking TSH-R ab. The prevalence of TSH-R ab was 3% in the euthyroid patients, without surgery performed. 15% in the surgical patients, and 25% in the patients still on ATD. CONCLUSIONS: Many JGD patients were euthyroid at the long-term follow-up in spite of high TPO ab and Tg ab titers. Stimulating TSH-R ab were rare (13%). According to this presence of TPO ab, Tg ab or TSH-R ab does not predict the final outcome of JGD. Further studies are needed.
Authors:
L Lavard; H Perrild; B B Jacobsen; M Høier-Madsen; G Bendinelli; P Vitti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Autoimmunity     Volume:  32     ISSN:  0891-6934     ISO Abbreviation:  Autoimmunity     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-02-14     Completed Date:  2001-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Hillerød Sygehus, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Autoantibodies / blood*
Child
Denmark
Female
Follow-Up Studies
Graves Disease / blood*,  drug therapy
Humans
Iodide Peroxidase / immunology*
Male
Receptors, Thyrotropin / immunology*
Retrospective Studies
Thyroglobulin / immunology*
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Receptors, Thyrotropin; 9010-34-8/Thyroglobulin; EC 1.11.1.8/Iodide Peroxidase

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