Document Detail


Prevalence of thiamine deficiency at a drug rehabilitation centre in Malaysia.
MedLine Citation:
PMID:  17623950     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A possible outbreak of beriberi occurred at a drug detention and rehabilitation centre, Pusat Serenti Bukit Cabang, Perlis, Malaysia in February 2004. This outbreak was identified following the presentation of a large number of inmates at a health centre with signs and symptoms of ankle oedema and shortness of breath. Further investigations revealed the death of three inmates at the General Hospital with similar clinical presentations during the period from October 2003 till February 2004. A cross sectional comparative study was carried out at the rehabilitation centre to find out the prevalence of thiamine deficiency among the inmates both symptomatic and asymptomatic. A total of 154 inmates were examined (57 symptomatic and 97 asymptomatic cases). It was found that 74% from the sample study (114 cases) had thiamine deficiency (44 symptomatic and 70 asymptomatic). Further statistical analysis showed that ankle oedema is consistent with the diagnosis of thiamine deficiency but lack sensitivity (p < 0.05, sensitivity 24.6%, specificity 95%). This outbreak could have been triggered by poor diet intake of thiamine by the inmates coupled with possible intake of certain thiamine antagonists in their diet.
Authors:
K Fozi; H Azmi; H Kamariah; M S Noor Azwa
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Medical journal of Malaysia     Volume:  61     ISSN:  0300-5283     ISO Abbreviation:  Med. J. Malaysia     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-07-12     Completed Date:  2007-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361547     Medline TA:  Med J Malaysia     Country:  Malaysia    
Other Details:
Languages:  eng     Pagination:  519-25     Citation Subset:  IM    
Affiliation:
Kangar Health Clinic, Perlis.
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MeSH Terms
Descriptor/Qualifier:
Adult
Beriberi / epidemiology*
Cross-Sectional Studies
Humans
Malaysia / epidemiology
Male
Middle Aged
Substance Abuse Treatment Centers / utilization*
Thiamine Deficiency / epidemiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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