Document Detail


Prevalence and subclass distribution of IgG-anti-IgE autoantibodies in atopy and parasitosis.
MedLine Citation:
PMID:  1804800     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using immunoblotting, we investigated sera of 60 patients with atopic dermatitis, 12 patients with helminth infections and 36 nonallergic controls, for anti-IgE autoantibodies. We found IgG anti-IgE autoantibodies in 62% of the atopics, 42% of the patients with parasitosis and 11% of the controls. IgG anti-IgE occurred most often (94%) in patients with atopic dermatitis plus additional atopic disorder, such as allergic asthma and rhinoconjunctivitis. In parallel, we found a significantly higher occurrence of IgG anti-IgE in the patients with high IgE levels compared to patients with low IgE levels (p less than 0.0005). The predominant subclasses of anti-IgE autoantibodies were IgG1 and IgG3 in atopy and parasitosis. In the controls, we found IgG4 and IgG3 anti-IgE, but no IgG1 autoantibodies. The frequency of IgG2 anti-IgE was very low; it occurred in 2 patients only. Prevalence and IgG subclass distribution of anti-IgE autoantibodies was found to be different for patients with atopic dermatitis, parasitic infection and for controls.
Authors:
A Scheuer; H Haas; M Schlaak
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  96     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-05-01     Completed Date:  1992-05-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  271-6     Citation Subset:  IM    
Affiliation:
Research Institute Borstel, FRG.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Anti-Idiotypic / immunology*
Autoantibodies / immunology*
Blotting, Western
Humans
Hypersensitivity / immunology*
Immunoglobulin E / immunology*
Immunoglobulin G / immunology
Immunoglobulin Isotypes / immunology
Parasitic Diseases / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Autoantibodies; 0/Immunoglobulin G; 0/Immunoglobulin Isotypes; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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