| Prevalence and stability of human serum antibodies to simian virus 40 VP1 virus-like particles. | |
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MedLine Citation:
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PMID: 15914848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Possible human infection with simian virus 40 (SV40) has been of great concern ever since SV40 was discovered in polio vaccines. Human populations are SV40-seropositive, but because of serological cross-reactivity between SV40 and the human polyomaviruses BK virus (BKV) and JC virus (JCV), it is debatable whether these antibodies are specific. An SV40-specific serological assay was established, based on purified virus-like particles (VLPs), where the SV40 VLPs were blocked with hyperimmune sera to BKV and JCV. Competition with SV40 hyperimmune sera was used as a confirmatory test. Among 288 Swedish children of between 1 and 13 years of age, 7.6 % had SV40-specific antibodies. SV40 seroprevalence reached a peak of 14 % at 7-9 years of age. Among 100 control patients with benign tumours, 9 % were SV40-seropositive. However, SV40 DNA was not detectable in corresponding buffy-coat samples. In serial samples taken up to 5 years apart from 141 Finnish women participating in the population-based serological screening for congenital infections, only two of 141 women were SV40-seropositive in both samples. Six women seroconverted and eight women had a loss of antibodies over time. None of the SV40-seropositive samples contained detectable SV40 DNA. In conclusion, there is a low prevalence of SV40-specific antibodies in the Nordic population. The SV40 antibodies appear to have a low stability over time and their origin is not clear. |
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Authors:
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Annika Lundstig; Linda Eliasson; Matti Lehtinen; Kestutis Sasnauskas; Pentti Koskela; Joakim Dillner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of general virology Volume: 86 ISSN: 0022-1317 ISO Abbreviation: J. Gen. Virol. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-25 Completed Date: 2005-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: England |
Other Details:
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Languages: eng Pagination: 1703-8 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, Malmö University Hospital, Entrance 78, 20502 Malmö, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antibodies, Viral / blood* Child Child, Preschool Enzyme-Linked Immunosorbent Assay / methods Female Finland / epidemiology Humans Immunologic Memory Infant Polyomavirus Infections / epidemiology* Seroepidemiologic Studies Simian virus 40 / immunology* Species Specificity Tumor Virus Infections / epidemiology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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