Document Detail


Prevalence and stability of human serum antibodies to simian virus 40 VP1 virus-like particles.
MedLine Citation:
PMID:  15914848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Possible human infection with simian virus 40 (SV40) has been of great concern ever since SV40 was discovered in polio vaccines. Human populations are SV40-seropositive, but because of serological cross-reactivity between SV40 and the human polyomaviruses BK virus (BKV) and JC virus (JCV), it is debatable whether these antibodies are specific. An SV40-specific serological assay was established, based on purified virus-like particles (VLPs), where the SV40 VLPs were blocked with hyperimmune sera to BKV and JCV. Competition with SV40 hyperimmune sera was used as a confirmatory test. Among 288 Swedish children of between 1 and 13 years of age, 7.6 % had SV40-specific antibodies. SV40 seroprevalence reached a peak of 14 % at 7-9 years of age. Among 100 control patients with benign tumours, 9 % were SV40-seropositive. However, SV40 DNA was not detectable in corresponding buffy-coat samples. In serial samples taken up to 5 years apart from 141 Finnish women participating in the population-based serological screening for congenital infections, only two of 141 women were SV40-seropositive in both samples. Six women seroconverted and eight women had a loss of antibodies over time. None of the SV40-seropositive samples contained detectable SV40 DNA. In conclusion, there is a low prevalence of SV40-specific antibodies in the Nordic population. The SV40 antibodies appear to have a low stability over time and their origin is not clear.
Authors:
Annika Lundstig; Linda Eliasson; Matti Lehtinen; Kestutis Sasnauskas; Pentti Koskela; Joakim Dillner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of general virology     Volume:  86     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1703-8     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, Malmö University Hospital, Entrance 78, 20502 Malmö, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies, Viral / blood*
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay / methods
Female
Finland / epidemiology
Humans
Immunologic Memory
Infant
Polyomavirus Infections / epidemiology*
Seroepidemiologic Studies
Simian virus 40 / immunology*
Species Specificity
Tumor Virus Infections / epidemiology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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